[em88]

Oh, God.

[em88]

Way too much TEA! 
Check the pH!!! 

[em88]

By glycol, I believe you mean propylene glycol. And yes, you mix the ingredient in glycerin or propylene glycol. The ingredient will not be dissolved, it will be dispersed and you will get some kind of slurry (it depends on the quantity of the ingredient you are dispersing or the quantity of glycerin/propylene glycol). 
Once the dispersion is ready, you add it to your emulsion while stirring it slowly till it is homogenized. 

[em88]

I haven’t read all the posts and maybe someone already said it, but remove the water and I don’t see any point in adding aloe there.
PG is way too low. 

[em88]

Pretty sure you are not dispersing carbomer properly. 

[em88]

Increasing the percentage of alcohol, will not make the product more effective! Do not attempt to do this product without spending some time learning how what and why does each product in the formulation. 

[em88]

as @Chemist77said, PEG 400 would help as well, and PG should be dropped to 5% max. 

[em88]

@Pharma, you said “it takes the fun out of the game and I consider it cheating” if this is not complaining then I don’t know what to say.
I’m not so sure if you really understand the meaning of having soul. 
Regarding the water expression, it was a hyperbole. Lol
Anyway, have fun formulating peg free products   

[em88]

@Pharma you were complaining about PEGs existence as they are a bad thing. Is like saying, water is great and everything, but what’s the fun of surviving without it? 
@Perry made a good point, I know of such people so I’m not going to comment anymore regarding this topic. 

[em88]

@Pharma, PEGs are great. As a pharmacist you should appreciate them. PEGs can be used in semisolids and solids, with many good functions! I’m working on a study to increase the bioavailability of a drug. PEGs have soul and give life to other substances. 

[em88]

@Pharma, the name was Lanette N. As I said it is a great ingredient for pharmaceutical oriented products. I used to make this myself before, but in an industry it is more easy to use a ready made mix. In pharmaceutical industries, the main point of choosing an expuent is its function, and as you said, this is a functional one. We don’t have to sound smart, but efficient. 😉
Regarding the feel. I’d say that it is good enough. It really depends on the purpose of the product and where it is going to be applied. 

[em88]

https://www.ulprospector.com/en/na/PersonalCare/Detail/33214/708848/Kolliphor-Cs-A great product if you are in pharmaceutical development 

[em88]

Doreen said:

@Pharma
I still use them! I’ve got a deck of 100% plastic poker cards for this reason. 😀
I’m not superstitious, but when I used the Joker last week, my emulsion failed! (Well, the emulsion itself was fine but I accidentally knocked over the mortar.) :joy: :joy:

I do try formulations in a mortar too. 
I’d recommend to use pvc (raw material) for blister packaging. :smiley: or you can use the plastic from bottles as-well. 

[em88]

@Perry, you can’t make any precise decision just by looking the samples.
I just remembered a similar situation at the university, It is very simple to have a fairly good precision if you do an experiment based on Hoppler viscometer.
I’d suggest to amitvedakar to read about the Hoppler viscometer and how to simulate it.   

[em88]

ngarayeva001 said:

There is a limit. Your salt curve will go down and you lose all viscosity. You need to do the analysis and find the peak

Yes, but no one stops you to add 3% of salt even if the viscosity is the same as 0.5% NaCl :smiley:
Jokes aside, yes, you are right regarding the salt curve, but I don’t think amitvedakar has the equipment to measure the viscosity. 

[em88]

Yes you can add NaCl up to 2% (I don’t think that there is any limit for NaCl), but you won’t need that much. 1% should be OK.
Don’t forget to make sure NaCl is well dissolved in your shampoo before checking the viscosity. 

[em88]

What’s the viscosity you are looking for and what’s the viscosity you are getting? What’s the pH of you shampoo? 
NaCl is cheap and easy to be added during manufacturing.  

[em88]

As Perry said, we as well have 2+ supplier for most of APIs and excipients. When you register/notify a new product you register both of manufactures.
5x MOQ can be much, but sometimes it can be supported if you have big batches. You can make a contract in which you specify in how many portion you can take the new MOQ in a specific period of time. In this way you don’t have to buy all the quantity at once. 

[em88]

Doreen said:

@em88
You’re a pharmacist too if I remember correctly. You can ask Perry to put it behind your name, like Pharma has. 
I thought I’d mention it as I know that you have so much professional knowledge.

Thanks for the the kind words. You are right I’m a pharmacist,  and more exactly a pharm.D. , but it is not necessary to add it in my username. 

[em88]

Pharma said:

Me, I never had any success when using patents as guidelines/starting point for stuff to create (wasn’t cosmetics, though).

I’ve been working with patents for several years, and my experience is a mixed up one. I have red patents which were very good and could learn things from, others were things which could not be applied in normal industrial enoirment, and others were basically wrong. But it is worth to read patents when you can find them. 

[em88]

jackleon80s said:

em88 said:

jackleon80s said:

em88 said:

Microformulation said:

No, and only for the reason that any Formulator MUST know how to check a patent.  If you are selling a product, a patent search is part of the Product Development phase.

Go to Google patents and do a search. It will help in this case as well as future products. https://patents.google.com/

Are you kidding me? How did you assume, I did not know how to search for patents? As a researcher, citations are a must when writing other’s work!
I only asked for the patent number, 1 because you already red/had it, and 2 I was on my phone. 
For your information, Google patents is not the best database for patents.
Now we should be afraid even to ask for the information source? That’s pathetic. 
Back to the topic. That patent had a few “mistakes”, probably to avoid publishing information.
Ketoconazole shampoos have two major problems, one is solubility and the second is stability of the api. Both of these problems can be solved. There are a few threads here (I’m on mobile and I can’t find right now the search option in this forum to link the threads) that may provide some info.. Since the level of egoism is so high and there are so many quick smart people in this thread I’m not going to write my personal research here (and I have already solved these problems). 

Why do people bother to help when they don’t like doing it,resulting in the end being impolite?

Thanks, this is the type of reply I was looking for. I know it’s not easy to formulate with Ketoconazole, and I have indeed did several searches to find how to formulate it into a shampoo with no success. 

If you can point me in the right direction on how to solve these two major problems, that would be very helpful.

I will write you privately, tomorrow (it’s too late now in my country)  and will direct you to the right problems so you can understand and solve your formulation by yourself.

Thank you, looking forward!

Done. Hope it will help you to get things started. 

[em88]

jackleon80s said:

em88 said:

Microformulation said:

No, and only for the reason that any Formulator MUST know how to check a patent.  If you are selling a product, a patent search is part of the Product Development phase.

Go to Google patents and do a search. It will help in this case as well as future products. https://patents.google.com/

Are you kidding me? How did you assume, I did not know how to search for patents? As a researcher, citations are a must when writing other’s work!
I only asked for the patent number, 1 because you already red/had it, and 2 I was on my phone. 
For your information, Google patents is not the best database for patents.
Now we should be afraid even to ask for the information source? That’s pathetic. 
Back to the topic. That patent had a few “mistakes”, probably to avoid publishing information.
Ketoconazole shampoos have two major problems, one is solubility and the second is stability of the api. Both of these problems can be solved. There are a few threads here (I’m on mobile and I can’t find right now the search option in this forum to link the threads) that may provide some info.. Since the level of egoism is so high and there are so many quick smart people in this thread I’m not going to write my personal research here (and I have already solved these problems). 

Why do people bother to help when they don’t like doing it,resulting in the end being impolite?

Thanks, this is the type of reply I was looking for. I know it’s not easy to formulate with Ketoconazole, and I have indeed did several searches to find how to formulate it into a shampoo with no success. 

If you can point me in the right direction on how to solve these two major problems, that would be very helpful.

I will write you privately, tomorrow (it’s too late now in my country)  and will direct you to the right problems so you can understand and solve your formulation by yourself.

[em88]

Microformulation said:

No, and only for the reason that any Formulator MUST know how to check a patent.  If you are selling a product, a patent search is part of the Product Development phase.

Go to Google patents and do a search. It will help in this case as well as future products. https://patents.google.com/

Are you kidding me? How did you assume, I did not know how to search for patents? As a researcher, citations are a must when writing other’s work!
I only asked for the patent number, 1 because you already red/had it, and 2 I was on my phone. 
For your information, Google patents is not the best database for patents.
Now we should be afraid even to ask for the information source? That’s pathetic. 
Back to the topic. That patent had a few “mistakes”, probably to avoid publishing information.
Ketoconazole shampoos have two major problems, one is solubility and the second is stability of the api. Both of these problems can be solved. There are a few threads here (I’m on mobile and I can’t find right now the search option in this forum to link the threads) that may provide some info.. Since the level of egoism is so high and there are so many quick smart people in this thread I’m not going to write my personal research here (and I have already solved these problems). 

Why do people bother to help when they don’t like doing it,resulting in the end being impolite?

[em88]

Microformulation said:

You can answer these questions and more by doing a simple Google search. The J&J patent describes the Formulation.

May I know the patent number? 

[em88]

Hec is a good start, the percentage depends on the type of hec. For higher cellulose mass you will need a lower percentage.