em88
Forum Replies Created
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You don’t need to add more emulsifiers as long as you are in the range of those products you mentioned in your first post. Get from the manufacturer more information regarding those products before using them!
Regarding stability, before fixing something check if it needs to be fixed Do some stability tests and if everything is fine don’t add ingredients which will only make the final product more expensive. -
em88
PharmacistSeptember 8, 2017 at 2:49 pm in reply to: Alternatives to propylene glycol as a salicylic acid solubilizer?Waiting for a feedback!
Good luck! -
Normally gelling agents do not have emulsifier properties. Those you have listed have the property to emulsify (because are composed by more than one ingredient) and better they can be used in cold process! I believe those are on the expensive part of ingredients
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@DRBOB@VERDIENT.BIZ thank you! I will google about the foam height test
@Microformulation thank you! Unfortunately the link provided in the thread you mentioned is not available anymore. Still I will try to find something regarding the test you mention. -
Try sepineo p600. It should make a cream translucent and trasparent + watery when applied on the skin. As you know it will depend on the oil faze you will add. You should stick to trasnparent oils like paraffin oil…
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I agree with Perry. It is impossible to have a transparent final product, when creams have 2 fazes in which a faze is dispersed in the other.
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em88
PharmacistSeptember 4, 2017 at 12:47 pm in reply to: Alternatives to propylene glycol as a salicylic acid solubilizer?How much SA do you want to dissolve? What do you want to obtain?
Propylene glycol + ethanol + glycerine should do the job. -
Wouldn’t a gelifying agent do the job?
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This seems spammy…. No information/description of what you are selling.
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You should look for designers. There are many designers which can do a custom box design!
Search on Google/Alibaba for package manufacturers. -
I’m also considering to add ZnO in the composition.
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http://i.imgur.com/CkG2dSO.jpg
Based on my experience, spiral propeller worked better in making creams compared with dispersing homogenizing blade.
For HEC gels I have only used the spiral propeller, not sure if other type of blades would work better.
@Perry, what is your experience with blade paddle and umbrella type blade? -
You will not have the same results by changing NaOH with TEA based on their molecular weight.
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If used in high concentration NaCl will dry the skin and hair which may lead to hair loss.
That still shouldn’t be a problem. Just imagine all we all go to the beach and the salt in the water is probably over 3.5% -
These kind of premixes have so many advantages and the best thing I like is the way they form gels, very fast and with low stirring speed, in fact you don’t even need a stirrer, just manual stirring is enough.
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em88
PharmacistJuly 26, 2017 at 2:03 pm in reply to: Lactic acid & salicylic acid for warts and verrucasThe closed case I found is a study with glycolic acid and salicylic acid 2% where they mention it has effect for warts.
All three ingredients have keratolyic effect which is the main mechanism effect thought till now for warts.
The main problem I found with lactic acid is that is has the lowest keratolytic effect compared to the other two ingredients due to the fact it does not penetrate very well the skin. -
You can use cold emulsifiers which tend to be more expensive that usual emulsifiers and you can only use liquid oil faze, or do as Belassi said, add ingredients which are not stable in higher temperature when the emulsion is cooling.
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The concentration for benzyl alcohol used for topical formulation is up to 2%, but benzyl alcohol is active in pH below 8, if I’m not mistaken, and the optimum pH should be up to 5
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And remember to get micronised particles to make the manufacturing process easier.
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Yes it did, but I like creams with good viscosity. Also it depends on the formulation. Best thing is to start with 0.25%.
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I have used only once HEC 1% and it increased the viscosity a lot. It also gave a very pleasant appearance to the cream (creammy, soft). I was unsure to go with HEC or xanthan gum, but once I saw the result with HEC, I didn’t even try xanthan gum. Currently the formulation is in the stability test, but it should do well.
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I have samples for both of premulen types, but never used, Are those considered expesive emulsifiers?
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Nice detailed info! Thank you