em88
Forum Replies Created
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Thank you! Will read again the MSDS.
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Just put the open package in normal stability test and check after 6, 9 and 12 months
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The title is a bit misleading… I thought he indeed was/is a member of this forum.
As Lainee said I tend to believe it is a fake news. -
Parabens
Imidurea -
Thank you!
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What about any special specification regarding the environment?
I can’t find anything an info source regarding this API.
Thank you for your reply! -
Sorry to bring this post up again, but does anyone still have the PDF?
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Exactly. I want to avoid this issue. Anyway till avoiding it I have to deal with the data regarding accelerated condition, which are failed for 2 months of stability….
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Yes.
Many products have specified the shelf life (for ex. 2 years) and shelf life after the first use (for ex. 6 months)
That is what I’m trying to determine. -
By unseal tube, I mean it has the cap closed, but the tube itself is unsealed. So the test is made to have an idea of how stable the product is after the first use.
From what I have seen, the stability test in accelerated condition is not very reliable for semisolids. Keeping the cream in high temperature and high humidity for a long period of time (2-6 months) will almost always result in degradation/faze separation etc. -
The main reason was to have an idea about the stability of the cream after the tube was opened. Normally the shelf life of an unsealed cream is less than one sealed.
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Salicylic acid at 1% level should be easy to deal with.
Dissolve 1% SA in 2.5% ethanol and add 17.5% PG No heat needed. -
@Belassi It is used as antioxidant, it will increase the stability of the API
@Bill_Toge, HEC is the first ingredients which is used to make the gel and than the rest of ingredients is homogenized in it (using temperature 60-70 C)
I first suspected about HEC to be separated, but the quantity used is less than 0.4% while the crust formed is between 5-10%. -
Since we are talking about the thickener, anyone is using Glucamate™ DOE-120 thickener?Source: https://www.lubrizol.com/en/personal-care/products/product-finder/products-data/163?productname=Glucamate%E2%84%A2%20DOE-120%20thickener
It’s not cheaper, not sure about healthier since the concentration needed is very little (based on some formulation I’ve seen). -
It is homogenized with standard homogenizers used for semisolids and shampoos. The mixing speed is indeed 60 RPM (if I’m not wrong, will confirm it shortly). The formulation is made with two different homogenizers (smaller and bigger), but the result is basically the same. What is the average time to let the shampoo in repose state? Will it be better if the time is longer, lets say a few days, or a week?
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So water is around 55%. First thought was, SLES was in high concentration, but reducing it, did not improve anything. I’m going to add each separately one by one and see when and what happens after each ingredient.
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Oh, I see! Thank you
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Am I the first one who is going to test this API here? :smiley:
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There are many companies which may manufacture drugs with higher toxicity APIs, it doesn’t mean that anyone can do w/o taking some measurements.
As I asked in my previews post, I’m not sure if there are requirements to fulfill for manufacturing products which contains ZPT. -
@DAS, whats wrong with NaCl?
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Doesn’t Zinc Pyrithione have special requirement in industrial use due to its toxicity? I have it at 48% and still risky when I red the safety data sheet.
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It is a hot process. I was thinking the same.
Next time I will take a sample and put it in a small container and seal it to see if it behaves the same as the rest of the product.Thank you for the help everybody!
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It has a lot of water, I will come tomorrow with the percentage of the water if needed. Adding more water will indeed reduce the foam but the product itself when used to wash doesn’t foam that much like in commercial shampoos.
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The shampoo stays in the container of the machine where it is homogenized, which has a big lid.
@Perry, yes, but the loss is around 5-10% which I think it is too much. How much glycerin would you suggest to add?
Any other idea? Would it help to put the shampoo to an other container(s)? -
Sorry, you are right. Below are the ingredient used. w/o means without api. The api is added as the final step.
Sodium Laureth Sulfate, Cocamidopropyl Betaine, Disodium Laureth Sulfosuccinate, Hydroxyethylcellulose, Butylated Hydroxyanisole, TEA, NaCl