Agate
Forum Replies Created
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Very interesting, thanks for sharing!
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1) I just read this today, maybe it helps: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804833/ It does appear to be funded by the manufacturer of Alpecin Liquid, but I found it interesting that 0.2% caffeine was found to be as effective as 5% minoxidil (rogaine). That doesn’t mean I suggest you use 0.2% caffeine in your shampoo, it’s just to show that it probably can do something.2) As far as I’m aware, the toxicity of caffeine powder is based on ingestion, being lethal in the region of about 10g. Irritation in the above study was reportedly lower than with minoxidil.
3) No idea.
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(Found the source again, just adding it here for good measure in case someone is interested: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615394/)
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I’m confused, what type of product are you trying to make?If you’re just looking to solve your own seborrheic dermatitis, I would look into a shampoo containing the antifungal agent ciclopirox olamine. I can’t find the source anymore, but read that unlike with ketoconazole, malassezia doesn’t adapt to it, so it stays effective in the long term. As a life-long sufferer of seborrheic dermatitis, this is the only thing I’ve found to keep it under control permanently for me.
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There may be a bit more than just marketing, if you read this thread: https://chemistscorner.com/cosmeticsciencetalk/discussion/506/oils-in-shampoo
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I don’t think it’s entirely impossible, as I recently read this: https://www.chemistscorner.com/cosmeticsciencetalk/discussion/5997/oil-base-shampoo
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@Herbnerd Very helpful to me as well, thank you!
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Sadly it’s chemically impossible to bring the soap pH to the hair-friendly range that you mention. It stops being soap and becomes a mess with no surfactant power at all. MCT doesn’t change the pH. But you don’t have to take anyone’s word for it - get some pure liquid castile soap, add some MCT oil, a good helping of citric acid dissolved in water, stir and then “wash” your hair with it…Some people do wash their hair with soap at a pH of 9-10, but most struggle as it will cause a gunky build-up if used in hard water, and even in soft water, results are mainly unimpressive. Dr. Bronner’s say it themselves on their website: “Dr. Bronner’s soaps clean your hair and scalp amazingly well, but they can also leave your hair feeling tangly and matted.”If you want to get into shampoo bars, have a look over here: https://www.swiftcraftymonkey.blog/questions-and-answers-about-shampoo-bars-the-master-list/
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“No Poo” is the little brother of “chemical-free”.Some don’t wash at all, others only wash with water. Many use baking soda and/or vinegar, or soap. Less popular options include clay, rye flour, egg, herbal concoctions with soap nut and many more. Others call it No Poo if they use a sulphate- and/or silicone-free shampoo, which is a crazy thing to lump together. I’m sympathetic to trying to do things differently, but find No Poo an unhelpful term because the room for interpretation is ludicrously big.
I wouldn’t be surprised if we come back to good old masking body odours with perfume instead of washing with these trends.
With all the glowing reviews, I’ll admit I’m intrigued: https://www.livinglibations.com/us/poetic-pits-classic -
Sterillium Gel uses Tetrahydroxypropyl Ethylenediamine (Neutrol TE). I keep mentioning it because I really do like its formulation, zero stickiness.
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Surely your client wouldn’t want to distribute a potentially ineffective product if they were aware of the issue.“Products with relatively low ethanol concentrations of up to 70 % (w/w)
usually are not sufficiently effective for hygienic hand disinfection,
when 3 ml are applied for 30 seconds. Particularly gels are considered
less effective than liquid products as they contain less ethanol. Also,
products with low ethanol contents hardly achieve virucidal activity.”75% Isopropanol blend shown to be effective against SARS-CoronavirusConclusion: “Consumers should be alerted to check the alcohol concentration in hand
sanitizers because substandard products may be marketed to the public.” -
@Padmavathi, fair enough, I would urge you to use at least 75% IPA, as per WHO guidelines.@bahey 40% ethanol isn’t proven to be effective against SARS-Coronaviruses (or many other viruses), it would be reckless to distribute this as a hand sanitizer. Please reformulate to contain 80% ethanol, again this is as per WHO guidelines.On a side note, Sterillium Gel also contains Cyclomethicone, which I imagine helps give it its smooth skin feel.
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Hi Padmavathi, not exactly what you’re asking about, but you may want to check out this recent thread: https://chemistscorner.com/cosmeticsciencetalk/discussion/comment/44450#Comment_44450I’d use a much higher percentage of IPA, Ethanol would be better if possible as it shows significantly better activity against viruses. The standard for most hospitals is 85% ethanol. 80% is generally good enough, I wouldn’t go much lower.You may want to add some glycerol, a maximum of 0.725% is recommended here: https://aricjournal.biomedcentral.com/articles/10.1186/2047-2994-2-34I have no experience with Ultrez 20 or 21, but I can see that the very popular hand gel that I use has Acrylates/C 10-30 Alkyl Acrylate Crosspolymer in it, and it leaves no sticky feel at all.
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Try searching for Trimethylglycine, it’s the same thing and you may find more suppliers.
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Perry is right, Bimatoprost is a drug. Its primary use is as a treatment for glaucoma, lowering the pressure inside the eye. Lash growth was only discovered as one of its side effects, which also include eye irritation and permanent dark pigmentation of the eyelids and irises.For your own safety and the safety of your customers, don’t mess around with Bimatoprost unless you are a pharmaceutical company.
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Found this: https://www.researchgate.net/post/Which_bacterias_exhibit_a_red_pigment_in_their_coloniesLooks like the red dot could be Serratia marcescens
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Can a lab used for challenge testing measure Aw of a sample?
As far as I’m aware, testing Aw requires specialised equipment, you’ll have to ask your lab if they have it or not.
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I’m in no way an expert like Perry or Belassi, but I’ve had similar issues with Decyl Glucoside as a primary surfactant: itchy, dry scalp, tangled hair.From my research it seems that if you’re trying to formulate for a customer who wants a “natural” shampoo (which I’m assuming from your formula) you could use Sodium Coco Sulfate, which still contains some Sodium Lauryl Sulfate but looks better on the label if that matters to you. It seems to be commonly mixed with Coco Glucoside, though I imagine it should be possible to make a reasonable blend with Decyl Glucoside.
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AMT (the producer of leucidal) recommends a combination with their fungicidal AMTicide Coconut, you can buy a combined product which is called Leucidal SF Complete.
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Second this, if you’re serious about it you need an experienced perfumer. The only way that you personally would recreate the same scent is through sheer luck.
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LuisJavier said:phenylethyl alcohol is such an interesting preservative/aroma material to me. How does it differ from phenoxyethanol in terms of antibiotic protection?
This may help: https://chemistscorner.com/cosmeticsciencetalk/discussion/6164/phenoxyethanol-replaced-by-phenethyl-alcohol
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Also be sure to use 70% ethanol as a bare minimum. Better and WHO-recommended is a concentration of 75-85%. High ethanol concentrations are especially important for virucidal action. Furthermore, ethanol is more effective against viruses than isopropyl alcohol. (“Ethanol, the most common alcohol ingredient, appears to be the most
effective against viruses; whereas, the propanols have a better
bactericidal activity than ethanol.” https://www.ncbi.nlm.nih.gov/books/NBK513254/) -
I just realized that the US models are obviously different, I’m not sure how the specs translate wattage wise, but it does appear to be the equivalent.
If maximum potential batch size is what matters to you, then there is one with a longer shaft: https://www.amazon.com/Bamix-Pro-3-Professional-Immersion-Blender/dp/B008ND7KYU I imagine it would be quite bulky for smaller batches though. Also bear in mind it won’t do slow stirring or stirring for long periods of time, so either you’ll need something else for that or know that you won’t be working with formulations like that, or be okay working around it by using high shear blending with periods of rest in between blending as a substitute, though I don’t know if that would always work. Really depends on your needs. -
It’s clear that the numbers don’t represent the true extent of the outbreak, but I wouldn’t worry about contracting the virus via shipments from China. Its close relative, the MERS-CoV can only remain viable on plastic and metal surfaces for 48 hours (https://www.ecdc.europa.eu/en/factsheet-health-professionals-coronaviruses), and similar values most likely apply to 2019-nCoV.