• Formulating

  What MW Polyisobutene does Sepiplus 400 use? FDA SRS registration.

  Posted by Zink on April 9, 2015 at 10:34 pm

  In the process of registering a OTC drug with the FDA, and you need to choose a MW according to their FDA Substance Registration System. Choices are:

  Polyisobutene 1300, 1000. 2300. 45000 or 55000 MW

  Zink replied 8 years, 8 months ago 3 Members · 6 Replies

  • fda
  • polyisobutene
  • sepiplus
  • srs
• 6 Replies

• 

  Bobzchemist

  Member

  April 10, 2015 at 4:18 am

  1300. The others are nasty.

• 

  MichelleReece

  Member

  April 10, 2015 at 4:25 am

  How are the other MWs nasty, @Bobzchemist?

• 

  Bobzchemist

  Member

  April 10, 2015 at 4:39 am

  Incredibly sticky and adhesive, near zero spreadability. STP oil treatment is~90% 45000.

• 

  Zink

  Member

  April 10, 2015 at 4:19 pm

  Wow, now that’s detailed knowledge! Neither the supplier Lotioncrafter or Seppic US knew.

• 

  Bobzchemist

  Member

  April 10, 2015 at 8:25 pm

  It helps when you’ve worked with the polyisobutenes before. The same properties that make them horrible for skin care make them AWESOME for mascara.

• 

  Zink

  Member

  April 12, 2015 at 2:16 am

  I find Sepiplus to work extremely well as an emulsifier in a emulsion containing benzoyl peroxide, where emulsifying wax nf wasn’t stable enough. Rub in is comparably good too.

  Any potential caveats?

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