Home Cosmetic Science Talk Formulating What MW Polyisobutene does Sepiplus 400 use? FDA SRS registration.

  • What MW Polyisobutene does Sepiplus 400 use? FDA SRS registration.

    Posted by Zink on April 9, 2015 at 10:34 pm

    In the process of registering a OTC drug with the FDA, and you need to choose a MW according to their FDA Substance Registration System. Choices are:

    Polyisobutene 1300, 1000. 2300. 45000 or 55000 MW
    Zink replied 9 years, 2 months ago 3 Members · 6 Replies
  • 6 Replies
  • Bobzchemist

    Member
    April 10, 2015 at 4:18 am

    1300. The others are nasty.

  • MichelleReece

    Member
    April 10, 2015 at 4:25 am

    How are the other MWs nasty, @Bobzchemist?

  • Bobzchemist

    Member
    April 10, 2015 at 4:39 am

    Incredibly sticky and adhesive, near zero spreadability. STP oil treatment is~90% 45000.

  • Zink

    Member
    April 10, 2015 at 4:19 pm

    Wow, now that’s detailed knowledge! Neither the supplier Lotioncrafter or Seppic US knew.

  • Bobzchemist

    Member
    April 10, 2015 at 8:25 pm

    It helps when you’ve worked with the polyisobutenes before. The same properties that make them horrible for skin care make them AWESOME for mascara.

  • Zink

    Member
    April 12, 2015 at 2:16 am

    I find Sepiplus to work extremely well as an emulsifier in a emulsion containing benzoyl peroxide, where emulsifying wax nf wasn’t stable enough. Rub in is comparably good too.

    Any potential caveats?

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