Home Cosmetic Science Talk Formulating What molecular weight of sodium hyaluronate is best for thickening?

  • What molecular weight of sodium hyaluronate is best for thickening?

    Posted by grapefruit22 on May 5, 2022 at 11:51 am

    Hi, I tried sodium hyaluronate at 0,50%, molecular weight ~ 1400 kDa. It was quite thick, but not enough. Moreover, there was also a feeling of tightening. Even at 1%, it was not thick enough, and the tightening effect was getting worse. I thought the sodium hyaluronate of this weight would act mainly as a lubricant and cannot have such an effect. Is it because the molecular weight is too low? I have other products that contain only sodium hyaluronate, low and high molecular weight, and even they do not cause such side effects and are very thick. What molecular weight is suitable for thickening?

    grapefruit22 replied 1 year, 9 months ago 4 Members · 4 Replies
  • 4 Replies
  • abdullah

    May 5, 2022 at 4:29 pm

    Those with higher molecular weight give higher viscosity. 

    A supplier suggested me 1.8 million Da at 0.1% but i didn’t purchase and use the product myself. 

  • paprik

    May 5, 2022 at 6:20 pm

    I think above 1000 kDa it is considered high molecular, but again, as Abdullah said, the higher the better (for gelling). I would say 1% is a decent (high) input and it probably does form a thicker layer that eventually dries thus the tightening. 
    Try to source higher MW and see how it goes. 

    Keep in mind, we do not know what is “thick enough” for you. :) You are maybe expecting too much from it? 

  • Rockstargirl

    May 6, 2022 at 12:18 am

    Oh boy! I just did this today. 6000 daltons be 1.5 million daltons. Sorry I can’t upload video .
    this 1% and HMW is THICK

  • grapefruit22

    May 6, 2022 at 3:47 pm

    @Abdullah, yes, now I’m looking something above 1800 kDa. The highest molecular weight I found is over 2000.
    @Paprik Yes, you are right, I wanted to take pictures of what viscosity I want to get, but the pictures were bad. Basically, I can accept a wide range of viscosity, that’s a secondary issue. The problem is that even when the product is a bit thin, it still causes a tight feeling. It leaves a very slight film on the face. Other products leave a more perceptible film, they are more thick, and this feeling of tightness is almost imperceptible.
    @Rockstargirl Thank you very much for the photos. Have you tried 1% HMW on your face?

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