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Home Cosmetic Science Talk Formulating Urea-ethanol reaction in skin sanitizers

  • Urea-ethanol reaction in skin sanitizers

    Posted by Anonymous on August 5, 2020 at 1:51 pm

    Hello everyone,
    I am formulating a liquid spray hand sanitizer containing 63% ethanol, 5% IPA, 2% glycerol and 2% urea. As far as I have tested it, it seems to be Ok, but recently I read about the reaction between ethanol and urea to produce ethyl carbamate, a skin carcinogen molecule. Nevertheless, It appears that such reaction takes place when heating urea and ethanol. My question is if it would be considered as dangerous a cosmetic product containing urea and ethanol?
    Thank you all for your comments

    Pharma replied 2 years, 9 months ago 1 Member · 1 Reply
  • 1 Reply
  • Pharma

    August 11, 2020 at 4:33 pm

    Unlikely to happen in your case, too much water present and not enough heat.