Two-Part Eczema Treatment
Good afternoon everyone,
I’ve been working on a treatment for someone with chronic and widespread eczema and I’ve found a combination that has shown minor results so far.
First, a 40% Urea Lotion is applied to eczema flare ups and left on for 20 minutes. Next, they shower to remove the cream and use a soft cloth to gently exfoliate their flare ups. Lastly, they apply a Colloidal Oatmeal & Ceramide Moisturizer.
The idea is that a high concentration of urea would act as a keratolytic agent and soften the top layer(s) of the flareups. Then that top layer could be gently removed in the shower and the skin underneath would be moisturized by the second product. I also expect that the petrolatum, mineral oil, and ceramides would help restore the skin’s barrier function. As a whole I hope the treatment will slow the skin’s turnover rate and help reduce the size of flare ups.
I consulted with a dermatologist before starting the treatment to be sure I wouldn’t be making anything worse. He recommended I add ceramides and HA (not convinced HA is doing any more than glycerin is) to the second step but besides that he said everything looked safe.
After a 3 weeks of use they said their flare ups felt less rough. At 5 weeks their flareups had more pigmentation (severe flare ups on African American skin look grayed out). At 6 weeks I took a look at the pictures before they started the treatments and I think the flare-ups have shrunk slightly but it isn’t very noticeable change. They have an overall decrease in itchiness.
I expected the treatment to have a more rapid effect. Because of this I’ve been a bit disappointed with the results (but hey at least I didn’t make it worse). Which leads me to my post and the following questions.
1) Is my understanding of how these products are affecting the skin sound?
2) Is there anything in my post that is incorrect/unclear?
3) Is there anything in the formulas you would change for better efficacy?
4) I’m thinking of increasing the time between applying the urea lotion and showering. How long can a 40% urea lotion be safely left on skin?
5) Does anyone have other ideas for reducing the size of flare ups?
6) How has your day been so far? : )
I’m about to leave work in a few minutes so I might not reply today but I will be sure to reply tomorrow.
Urea Lotion:DI Water 34.1998Carbomer 980 0.2500Light Mineral Oil 3.9000Snow White Petrolatum 10.0000Glyceryl Stearate SE 3.4000Cetyl Alcohol 5.0000Propylene Glycol 0.5000Xanthan Gum 0.0002Urea 40.0000Phenoxyethanol (and) Ethylhexylglycerin 1.000Vitamin E Acetate 0.500NaOH 1.2500Packaged in a plastic squeeze tube.
pH = 6.56
Colloidal Oatmeal & Ceramide Cream:
DI Water 57.600 Ceramide EOP (and) Ceramide NS (and) Ceramide NP (and) Ceramide
AS (and) Ceramide AP (and) Cholesterol (and) Hydrogenated Lecithin (and)
Glyceryl Stearate (and) 2,3-Butanediol
3.000 Acrylamide/Sodium Acrylate Copolymer (and) Paraffinum Liquidum
0.800 Disodium EDTA 0.100 C12-15 Alkyl Benzoate 1.500 Glyceryl Stearate (and) PEG-100 Stearate 2.500 Cetearyl Alcohol 2.500 Glycerin 4.000 Petrolatum 5.000 Shea Butter 1.000 Mineral Oil 1.500 Dimethicone 10000cst 3.000 Glycereth-26 1.000 DI Water 10.000 Colloidal Oatmeal USP 1.000 Aqua (and) Sodium Hyaluronate (1% Solution) 2.000 Sodium PCA (and) Wheat Amino Acids (and) Panthenol (and)
Glycerin (and) Sodium Hyaluronate (and) Hydroxyproline
2.500 Benzyl Alcohol (and) Benzoic Acid (and) Sorbic Acid 1.000 Triethanolamine q.s
Packaged in a plastic jar.
pH = 4.96