Home Cosmetic Science Talk Formulating tocopheryl acetate

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  • tocopheryl acetate

    Posted by P89 on February 12, 2021 at 9:17 pm

    Hi, i’m sorry if the question is stupid but:
    Tocopheryl acetate is insoluble in cold water but soluble in hot water. If i inserit it in a simple hyaluronic gel serum without lipidic phase, it will separate from the serum after a period?

    thank you very much

    P89 replied 3 years, 7 months ago 5 Members · 11 Replies
  • 11 Replies
  • Pattsi

    Member
    February 13, 2021 at 8:34 am

    Yes.

  • Paprik

    Member
    February 13, 2021 at 10:52 am

    Yes, you would need to solubilize the Vit E first. 

  • P89

    Member
    February 13, 2021 at 3:35 pm

    And can i solubilize it simply in hot water?

  • Paprik

    Member
    February 13, 2021 at 9:14 pm

    Nope, I think you don’t solubilize it in hot water, maybe only disperse? (I’d watch the temperature also, as vit. E is heat sensitive and oxidizes when exposed to high temperatures). Use something like Polysorbate 20, Caprylyl/Capryl glucoside or so. 

  • P89

    Member
    February 14, 2021 at 8:44 am

    i’ll try with them.

    glycerin can’t solubilize it? however i’m still reading that acetate form of vit E is hot water soluble. don’t you agree with it?

  • Paprik

    Member
    February 14, 2021 at 6:08 pm

    No, Glycerin doesn’t work as solubiliser. Solubiliser is basically liquid surfactant with very high +15 HLB. Glycerin is not a surfactant. 

    Could you maybe share where you’re getting the information from? 

  • Microformulation

    Member
    February 14, 2021 at 6:35 pm

    Tocopheryl acetate is insoluble in water, regardless of temperature. Glycerin would not solubulize it into an aqueous base. There are numerous credible references to find this information.

  • P89

    Member
    February 14, 2021 at 7:34 pm

    Paprik said:

    No, Glycerin doesn’t work as solubiliser. Solubiliser is basically liquid surfactant with very high +15 HLB. Glycerin is not a surfactant. 

    Could you maybe share where you’re getting the information from? 

    i’m watching it in several italian sites and also a cosmetologist said it to me!  :'(

  • Microformulation

    Member
    February 14, 2021 at 10:00 pm

  • MarkBroussard

    Member
    February 15, 2021 at 12:53 am

    @p89:

    Tocopheryl Acetate is a rather useless ingredient … it does not perform well as an antioxidant and has only a 6% conversion rate when applied to the skin.  Unless you want it for label appeal, there is no benefit to adding it to your formulation.

  • P89

    Member
    February 27, 2021 at 6:55 pm

    It’s moreover for label. i think that i’ll solve with polygliceryl 4 caprate

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