Home Cosmetic Science Talk Formulating Tocopherol in Hair serum

  • Tocopherol in Hair serum

    Posted by OTosin on August 12, 2017 at 2:55 pm

    I created a formula composed of only oil. It contains some essential and carrier oils in the right proportions for hair. I am however, confused about tocopherol. I want to know:
    1. which is a better antioxidant, alpha or gamma?
    2. Which vitamin e oil contains the highest amount of the better antioxidant? i heard of t50 for gamma, but i’m not sure.
    3. what percetange of it should i add to my formular to ensure high anti oxidant activity, and also safety.

    OTosin replied 6 years, 2 months ago 4 Members · 7 Replies
  • 7 Replies
  • DRBOB@VERDIENT.BIZ

    Member
    August 12, 2017 at 3:33 pm

    We had good results using 5% VE with mixed isomers  —All involved patients were seen over an eight-week period, during which they were required to supplement their current acne regimen with topically applied vitamin E [tocopherol 5% (alpha 11.4%][delta 15%][gamma/beta 45%) in sunflower seed oil]. The supplemented regimen was applied once per day over an eight-week period.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756869/

  • microformulation

    Member
    August 12, 2017 at 5:39 pm

    To protect an anhydrous oil from oxidation, 5% Tocopherol is far too high.

  • DRBOB@VERDIENT.BIZ

    Member
    August 12, 2017 at 7:29 pm

    I am reading antioxidant efficacy in formula? VE for oil antioxidant use .05-.! % in which case isomer used becomes less important. 

  • OTosin

    Member
    August 12, 2017 at 10:39 pm

    ok thank you. but i’m still expecting the answer for which to use either alpha or gamma? and which oil contains the higher amount of the better one?

  • DRBOB@VERDIENT.BIZ

    Member
    August 13, 2017 at 8:37 pm

    Both have equivalent Redox potentials versus ROS on equimolar basis.Vegatable oils have low levels of both expressed in mg/KG so for antioxidant efficacy in an anhydrous hair product add 1% d alpha Tocopherol (BIOCHEMICA) to the oils you currently use.

  • doreen

    Member
    August 13, 2017 at 8:50 pm


    https://link.springer.com/article/10.1007/s11746-002-0433-6

    (Quote: “For example, the optimal concentrations for α-tocopherol and γ-tocopherol were ∼100 and ∼300 ppm, respectively, whereas δ-tocopherol did not exhibit a distinct concentration optimum at the levels studied (P<0.05). The optimal concentration for the natural tocopherol mixture ranged between 340 and 660 ppm tocopherols (P<0.05)”.)

    So their verdict is: 0,01% is the optimum concentration for alpha- and gamma tocopherol before it becomes pro-oxidative; 0,03-0,06% is the optimum dose for mixed tocopherols.

  • OTosin

    Member
    November 25, 2017 at 9:59 pm

    Thank you. So helpful!

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