Spray-on scalp formulationHey everyone,I’m David. While I don’t have a chemistry background, I’ve always had a fascination with the composition of practical products like soaps, cleaners, shampoos, etc. I like to read the ingredients of the products I come across and learn about the components I haven’t yet encountered.I’m working on a topical product for androgenic alopecia based primarily on active botanical components. Given the challenge of applying liquids to the scalp, I think that a spray-on formulation (i.e. low viscosity in a spray bottle) would make this process easier. The gist of this product is an ethanolic extraction from botanicals which is designed for transdermal penetration. As a result, the product must contain ethanol (at least, say, 20%).The active components are still a work in progress but will likely be an extraction including apple polyphenols (procyanidin B2), nigella sativa (thymoquinone), camellia sinensis (catechins; EGCG), and olea europea leaves (oleuropein). The extraction is performed using anhydrous ethanol at 40degC.In order to increase transdermal penetration, I’ve decided on the following base formulation:50% (v/v) ethanol30% (v/v) distilled water20% (v/v) 1,2-propanediolwithd-limonene (1.5% w/v)disodium EDTA (0.3% w/v)and a pH adjusted to 5.5 using citric acid.I don’t think a preservative would be necessary beyond a chelating agent given the high concentration of ethanol. Using less ethanol or a compound other than 1,2-propanediol may make the product more gentle but this specific base seems to be popular in research. I’d like to avoid DMSO in the formulation if possible. Finally, ideally the product should have a moderate shelf-life (i.e. at least six months at room temperature) but this isn’t a hard requirement.Does this general approach make sense? Also, given the mix of botanical products in the extraction, would adding an additional sequestrant like glucono delta-lactone and/or creating a moderate pH buffer make sense? Is there anything I’m missing here?Thanks, everyone!
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