Home Cosmetic Science Talk Formulating Skin Solibilizer recommendation

  • Solibilizer recommendation

    Posted by Anonymous on November 22, 2016 at 1:14 am

    I am trying to find a solubilizer to
    mix 1% licorice root extract (Glycyrrhiza glabra, water soluble), into a mixture of 99% carrier oils. 

    I’m inclined to try Polysorbate 80 but I’m not sure that’s the right direction to go in. 

    Do you think the Polusorbate 80 would be effective in this situation? Or is there something that would work better and be more stable?


    padech replied 6 years, 9 months ago 7 Members · 8 Replies
  • 8 Replies
  • crisbaysauli

    November 22, 2016 at 9:56 am

    if your licorice extract is water soluble, maybe you can request for an oil soluble one. this will make your formulation a lot easier to make. solvents like DPG, Mineral oil, Sunflower oil, etc can help.

  • Anonymous

    November 29, 2016 at 3:37 pm

    I have had very little success locating an oil soluble licorice extract. That’s why I need to find an effective solublizers. 

  • Belassi

    November 29, 2016 at 4:33 pm

    Not surprising. There are no oil-soluble licorice extracts, to my knowledge.
    Licorice’s active ingredient is glycyrrhizic acid; this is almost insoluble in water, insoluble in oils, really it’s only soluble in ethanol. The potassium and ammonium salts are soluble in water but not oil. Frankly I can’t see a way to do what you originally asked to do.

  • MarkBroussard

    November 29, 2016 at 5:23 pm

    If you’re looking for skin brightening properties, you would be better off using an oil-soluble Vitamin C

  • chickenskin

    November 30, 2016 at 4:38 pm

    Maybe emulsify it with something?  use cremophor (heating required) / poly 20?  I’d keep trying

  • Ameen

    December 1, 2016 at 11:13 am

    @ BobbiBenski

    Solubility of Glabridin 40 in various solvents


    Hope this helps

  • beautynerd

    December 5, 2016 at 3:52 am

     If you are intent on licorice, try:

    NET STG (Stearyl Glycyrrhetinat) by Maruzen Pharmaceuticals/Barnet Products - an oil soluble derivative more effective form of Glycyrrehetic acid, the key active in Licorice root

  • padech

    December 8, 2016 at 10:38 am

    Typically, the Licorice Root Extract is use Propylene Glycol as solvent. Please try to mix your extract with Span 80 before add to the carrier oil base. Start from ratio extract : span 80 at 1:5 then increase the span 80 part if the mixing it still not miscible completely.  

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