Home Cosmetic Science Talk General Signs of Nitrosamines being formed in Shampoo

  • oldperry

    Member
    September 3, 2020 at 12:12 pm

    Not that a person could sense. I suppose you could run a sample through an IR Spectrometer to identify the bonds.

  • ketchito

    Member
    September 3, 2020 at 12:59 pm

    @Abdullah Cocamide MEA and MIPA have very low risk of nitrosamine formation compared to DEA. If you’re worried about it’s possible formation, avoid preservatives as Bronopol or Bronidox which under certain conditions can act as Nitrosating agents that convert free diethanolamines (present in DEA derivatives) into nitrosamines. Formaldehyde can also catalyze the reaction. You can use some substances in your formula to also prevent is formation such as Ascorbic acid (other organic acids are weaker at preventing nitrosamine formation). This last technique is used in bakery and it’s recommended by COLIPA. So, generally speaking, you need all the “wrong” ingredients so it happens, and that’s why Cocamide DEA is still approved in cosmetics, as long as there are no nitrosating agents.

  • pharma

    Member
    September 3, 2020 at 7:04 pm

    Abdullah said:

    here any way…if nitrosamines are being formed…? 
    … Or another sign. 

    The only way most consumers could tell is (skin) cancer (but would be 10-20 years too late to do anything about it).

    Standard IR won’t cut it (unless the amount is through the roof).
    HERE some reading.
  • oldperry

    Member
    September 3, 2020 at 7:32 pm

    @Pharma - I don’t think the levels exposed to by cosmetics have ever been demonstrated to cause skin cancer.

  • pharma

    Member
    September 4, 2020 at 4:58 am

    Hopefully not. It’s just the only sign for their presence a consumer can get ;) .

  • abdullah

    Member
    September 4, 2020 at 12:23 pm

    Thank you all

  • abdullah

    Member
    September 4, 2020 at 12:25 pm

    @ketchito my preservatives are Ethyl Lauroyl Arginate HCl, glyceryl caprylate, caprylyl glycol, caprylhydroxamic acid

  • ketchito

    Member
    September 4, 2020 at 1:13 pm

    @Abdullah I believe there should be no problem with that preservative system. As a side note, check for the efficacy to see if there might be lack of activity against some specific microbial organism, and that the pH is adecuate for it to function properly.

  • abdullah

    Member
    September 4, 2020 at 1:25 pm

    @ketchito pH is between 5-5.5 

    The ratio of each preservative in blends we make is the same as preservatives from reputable companies like Inolex wich is broad spectrum. This way it cost much less than if we purchase the pre blend. 

  • ketchito

    Member
    September 5, 2020 at 1:46 pm

    @Abdullah I understand, but every formula has specific needs, and the ingredients you are listing as preservatives are actually preservative boosters rather than preservatives. Companies nowadays sell them as green or natural preservatives, but most of them lack of activity against specific strains. In very simple formulas, they might work more or less combined, but if you have extracts, proteins, starches, not only you’ll need higher amounts of some of them, they might fail to protect against certain microbes (not to mention that adding them in the wrong way to an emulsion, when you have solubilizers or emulsfiers, could get them out of your water phase, which is the one you want to focus on), so again, it depends on your formulation needs. 

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