Home Cosmetic Science Talk Formulating Skin Seborrheic Keratosis

  • Seborrheic Keratosis

    Posted by belassi on June 12, 2018 at 3:46 pm

    Currently working on this. (Yes I know, but I don’t live in the USA so I don’t worry about the FDA.)
    Looking for input from anyone else with an interest in SK. I have a candidate compound which shows promise: DMAE Tartrate. A 3% cream appears to have a discernible result. I’m thinking of adding urea to the mix, not sure what percentage of urea to use … I don’t want pH drift problems.

    belassi replied 5 years, 8 months ago 4 Members · 14 Replies
  • 14 Replies
  • em88

    Member
    June 13, 2018 at 11:08 am

    I’d suggest 5-10% urea. 
    As you said, urea will degradate and increase the pH. You will need a buffer to maintain urea stable. 

  • belassi

    Member
    June 13, 2018 at 5:30 pm

    Can you suggest a suitable buffer? Would sodium citrate work?

  • em88

    Member
    June 14, 2018 at 12:22 pm

    I made a water based solution which had salicylic acid/sodium citrate and urea. The pH was 5.5 and remained unchanged for a few days.
    I have seen some products in my local market with high concentration of urea (15%, 30%) which are w/o emulsions (creams). I think, the less water is used the better for urea is to be stable.

  • chemicalmatt

    Member
    June 16, 2018 at 4:24 pm

    Hola’ Belassi. Long time/no blog. Urea compositions are best stabilized with lactic/lactate buffers at pH <6.  The threshold of use for keratolysis is around 10%.  At 40% you can dissolve the nail sheath if left on overnight. Cool, huh? uhhh…maybe not.

  • belassi

    Member
    June 16, 2018 at 8:18 pm

    Unfortunately I have not been able to source any kind of lactic acid products here in Mexico. Maybe I should use yoghurt as a base!

  • belassi

    Member
    June 30, 2018 at 9:07 pm

    Extraordinary. The 3mm SK lesion on the back of my left hand has disappeared as a result of the DMAE tartrate cream. I had to use a x50 magnifier to find where it was. I am definitely going to market this.

  • em88

    Member
    July 2, 2018 at 11:36 am

    Glad to hear that. Does DMAE have any restriction for cosmetics? What was the LOI you used, if you don’t mind sharing?

  • belassi

    Member
    July 2, 2018 at 4:06 pm

    I find plenty of DMAET creams on Amazon so I assume it’s acceptable.

    PART A
    1) water
    2) carbopol-940
    3) sodium hydroxide
    4) propylene glycol
    5) pycnogenol
    6) glycerine
    7) parabens
    8) EDTA
    9) DMAET
    PART B
    10) shea butter
    11) stearic acid
    12) cetyl alcohol
    13) glycerol monostearate
    14) dimethicone petrolatum
    15) fragrance
    Not in particular order… it is basically a knock-off of the Evelyn and Crabtree hand cream. It’s one of the first products I created.
  • maria

    Member
    July 2, 2018 at 8:25 pm

    May I ask how long did you make use of this cream before the lesion was gone? No urea? 

  • belassi

    Member
    July 2, 2018 at 9:14 pm

    2 weeks but only every other day.

  • maria

    Member
    July 7, 2018 at 3:17 pm

    Thank you! I do have a small spot of SK and DMAE bitartrate waiting to be used. I’ll let you know if it works :)

  • belassi

    Member
    July 7, 2018 at 4:38 pm

    Good. I need to put together a test panel.

  • maria

    Member
    July 7, 2018 at 6:12 pm

    Ready!  :)

  • belassi

    Member
    July 7, 2018 at 11:19 pm

    LOL.
    Please let me know how it goes.

Log in to reply.