Seborrheic Keratosis - Chemists Corner

Skin

Seborrheic Keratosis

Posted by belassi on June 12, 2018 at 3:46 pm

Currently working on this. (Yes I know, but I don’t live in the USA so I don’t worry about the FDA.)
Looking for input from anyone else with an interest in SK. I have a candidate compound which shows promise: DMAE Tartrate. A 3% cream appears to have a discernible result. I’m thinking of adding urea to the mix, not sure what percentage of urea to use … I don’t want pH drift problems.

belassi replied 6 years, 4 months ago 4 Members · 14 Replies
14 Replies

em88

Member
June 13, 2018 at 11:08 am

I’d suggest 5-10% urea.
As you said, urea will degradate and increase the pH. You will need a buffer to maintain urea stable.
belassi

Member
June 13, 2018 at 5:30 pm

Can you suggest a suitable buffer? Would sodium citrate work?
em88

Member
June 14, 2018 at 12:22 pm

I made a water based solution which had salicylic acid/sodium citrate and urea. The pH was 5.5 and remained unchanged for a few days.
I have seen some products in my local market with high concentration of urea (15%, 30%) which are w/o emulsions (creams). I think, the less water is used the better for urea is to be stable.
chemicalmatt

Member
June 16, 2018 at 4:24 pm

Hola’ Belassi. Long time/no blog. Urea compositions are best stabilized with lactic/lactate buffers at pH <6. The threshold of use for keratolysis is around 10%. At 40% you can dissolve the nail sheath if left on overnight. Cool, huh? uhhh…maybe not.
belassi

Member
June 16, 2018 at 8:18 pm

Unfortunately I have not been able to source any kind of lactic acid products here in Mexico. Maybe I should use yoghurt as a base!
belassi

Member
June 30, 2018 at 9:07 pm

Extraordinary. The 3mm SK lesion on the back of my left hand has disappeared as a result of the DMAE tartrate cream. I had to use a x50 magnifier to find where it was. I am definitely going to market this.
em88

Member
July 2, 2018 at 11:36 am

Glad to hear that. Does DMAE have any restriction for cosmetics? What was the LOI you used, if you don’t mind sharing?
belassi

Member
July 2, 2018 at 4:06 pm

I find plenty of DMAET creams on Amazon so I assume it’s acceptable.

PART A

1) water

2) carbopol-940

3) sodium hydroxide

4) propylene glycol

5) pycnogenol

6) glycerine

7) parabens

EDTA
9) DMAET

PART B

10) shea butter

11) stearic acid

12) cetyl alcohol
13) glycerol monostearate

14) dimethicone petrolatum
15) fragrance

Not in particular order… it is basically a knock-off of the Evelyn and Crabtree hand cream. It’s one of the first products I created.
maria

Member
July 2, 2018 at 8:25 pm

May I ask how long did you make use of this cream before the lesion was gone? No urea?
belassi

Member
July 2, 2018 at 9:14 pm

2 weeks but only every other day.
maria

Member
July 7, 2018 at 3:17 pm

Thank you! I do have a small spot of SK and DMAE bitartrate waiting to be used. I’ll let you know if it works
belassi

Member
July 7, 2018 at 4:38 pm

Good. I need to put together a test panel.
maria

Member
July 7, 2018 at 6:12 pm

Ready!
belassi

Member
July 7, 2018 at 11:19 pm

LOL.
Please let me know how it goes.