Home Cosmetic Science Talk Formulating Salicylic acid in the cream formulation

  • Salicylic acid in the cream formulation

    Posted by mehrzadkia on October 27, 2018 at 5:20 pm

    Hello there.

    We have encountered a problem when using salicylic acid in the cream formulations; I feel like sand grains in the product when salicylic acid is used in the formulation. Supposedly, adding some kinds of chemicals to the formulation would do the trick! Do you have any idea how to solve this problem? 

    Thank you so much for your time.

    mehrzadkia replied 5 years, 4 months ago 8 Members · 14 Replies
  • 14 Replies
  • belassi

    Member
    October 27, 2018 at 5:22 pm

    How do you expect to get meaningful replies when we have no idea what your formula contains?

  • markbroussard

    Member
    October 27, 2018 at 5:25 pm

    It sounds like the Salicylic Acid is not properly solubilized and/or is precipitating out in the cream.  Not really possible to offer you more guidance without more detail on your formula

  • mehrzadkia

    Member
    October 27, 2018 at 5:36 pm

    Dear @Belassi,
    I thought there is something wrong, especially with Salicylic Acid. But yes, you are absolutely right. I will get back with details. Thank you.

    Dear @MarkBroussard,
    Thank you so much for your response.

  • fekher

    Member
    October 27, 2018 at 6:13 pm

    @mehrzadkia  may you need better  quality of salicylic acid , ”    smaller granulation powder” 

  • chemist77

    Member
    October 27, 2018 at 6:28 pm

    As Mark said, the acid should be solubilized and with the aid to keep it soluble. Else precipitation won’t be stopped. 

  • mehrzadkia

    Member
    October 27, 2018 at 9:24 pm

    Chemist77 said:

    As Mark said, the acid should be solubilized and with the aid to keep it soluble. Else precipitation won’t be stopped. 

    Thank you so much.
    Sorry, my question may sound stupid, but how can I keep the acid soluble? I mean, is there a special compound for this?

  • mehrzadkia

    Member
    October 27, 2018 at 9:25 pm

    Fekher said:

    @mehrzadkia  may you need better  quality of salicylic acid , ”    smaller granulation powder” 

    Thank you so much.

  • markbroussard

    Member
    October 28, 2018 at 12:40 am

    It’s really a function of you total formula pH … try to keep it around 4.0.  Again, without knowing you have in your formula it is not possible to tell what may be causing the SA to precipitate out.  Check your pH would be the first recommendation.

  • mehrzadkia

    Member
    October 28, 2018 at 6:19 am

    It’s really a function of you total formula pH … try to keep it around 4.0.  Again, without knowing you have in your formula it is not possible to tell what may be causing the SA to precipitate out.  Check your pH would be the first recommendation.

    I’m going to check the pH then. Hope it works out.
    Thank you very much. 

  • em88

    Member
    October 29, 2018 at 8:29 am

    That formula must be a state secret.  There are some ways to dissolve it without (partially) neutralizing it, but again the formula is needed. 
    Assuming the concentration of SA is up to 2% you should not have too much issues dissolving it. 

  • amitvedakar

    Member
    October 29, 2018 at 8:47 am
    Cream Base is unstablet for Salicylic Acid.
    Suitable base is Ointment.
    White soft Paraffin Base. Dissolve In hot Paraffin with continuous Stirring.
  • mehrzadkia

    Member
    October 30, 2018 at 9:19 am

    em88 said:

    That formula must be a state secret.  There are some ways to dissolve it without (partially) neutralizing it, but again the formula is needed. 
    Assuming the concentration of SA is up to 2% you should not have too much issues dissolving it.

    Thank you so much for your response.
    Yes the concentration is 2%. As one of the chemists here sugessted, the problem is probably with pH.

  • mehrzadkia

    Member
    October 30, 2018 at 9:23 am

    Cream Base is unstablet for Salicylic Acid.
    Suitable base is Ointment.
    White soft Paraffin Base. Dissolve In hot Paraffin with continuous Stirring.

    Thank you so much.
    It’s true for sure, but we the point is we want salicylic acid to make creams, not ointment. Great point though! Thank you.

  • ngarayeva001

    Member
    October 30, 2018 at 1:12 pm

    Propanediol and propylene glycol are good solvents for salicylic acid. I disagree that cream base is not good for salicylic acid. La Roche Posay uses a combination of salicylic acid and niacinamide in their Effaclar line for a blemish prone skin. And it’s rather effective although they use concentrations of SA below 1%.  SA will act as a peel at 2% if you keep the pH low. If you want to use it as a peel, serum like formula would work better.

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