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Progesterone Cream
Hello Formula Peeps!
Any tips on formulating with progesterone? e.g. Interactions, pH considerations, solubilizers, etc….
I have all the safety stuff and experience to handle this chemical (professional lab, fume hood, respirator, sleeve gloves). Not a kitchen cook fyi.
Also I’d gladly pay someone for a 30 min discussion about this too. Just DM me.
Thank you!
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4 Replies
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Some thoughts:- Given your nickname I assume you’re female. Else, it is recommended not to handle female hormones (at least not on a regular basis), even with your safety equipment.- Progesterone is considered a prescription drug in many countries.- It isn’t that pH sensitive, best to keep it below pH 7.- Interactions: Could you be more precise? Chemically, it’s quite stable, if that’s what you’re asking. Just to be on the safe side, don’t combine with good nucleophiles such as free thiols.- It’s best soluble in medium polarity solvents such as alcohols (progestogel, a pharmaceutical product, is a hyroalcoholic gel). What you could or have to use depends on the final concentration and where that cream will be applied.- You could also go for a suspension instead of a solution: jojoba oil is used in magistral preparations to obtain a 10% stock suspension which can then be integrated into oilier creams.- Other preparations such as vaginal suppositories (suspensions, not solutions) are based on macrogols.May I ask what you’re planning? What you’re planning doesn’t sound like cosmetics… -
Thank you for the thoughts on this. For interactions you answered what I was looking for. My plan is to make a cream with about 10%-15% Progesterone. This will not be labeled with any claims or intended use/dosage. Can’t find much on the web beyond basic compounding formulas using stock base from PCCA.
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Great comments from pharma.
chickenskin said:
@PharmaThank you for the thoughts on this. For interactions you answered what I was looking for. My plan is to make a cream with about 10%-15% Progesterone. This will not be labeled with any claims or intended use/dosage. Can’t find much on the web beyond basic compounding formulas using stock base from PCCA.
No claims? Why are you using the stuff?
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Personal project no intention on developing beyond personal use.