Cosmetic Science Talk

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  • Progesterone Cream

    Posted by chickenskin on May 26, 2021 at 4:01 am

    Hello Formula Peeps!

    Any tips on formulating with progesterone?  e.g. Interactions, pH considerations, solubilizers, etc….

    I have all the safety stuff and experience to handle this chemical (professional lab, fume hood, respirator, sleeve gloves).  Not a kitchen cook fyi.

    Also I’d gladly pay someone for a 30 min discussion about this too.  Just DM me.  

    Thank you! 

    chickenskin replied 1 year, 8 months ago 3 Members · 3 Replies
  • 3 Replies
  • Pharma

    Member
    May 26, 2021 at 5:43 pm
    Some thoughts:
    - Given your nickname I assume you’re female. Else, it is recommended not to handle female hormones (at least not on a regular basis), even with your safety equipment.
    - Progesterone is considered a prescription drug in many countries.
    - It isn’t that pH sensitive, best to keep it below pH 7.
    - Interactions: Could you be more precise? Chemically, it’s quite stable, if that’s what you’re asking. Just to be on the safe side, don’t combine with good nucleophiles such as free thiols.
    - It’s best soluble in medium polarity solvents such as alcohols (progestogel, a pharmaceutical product, is a hyroalcoholic gel). What you could or have to use depends on the final concentration and where that cream will be applied.
    - You could also go for a suspension instead of a solution: jojoba oil is used in magistral preparations to obtain a 10% stock suspension which can then be integrated into oilier creams.
    - Other preparations such as vaginal suppositories (suspensions, not solutions) are based on macrogols.
    May I ask what you’re planning? What you’re planning doesn’t sound like cosmetics…
  • chickenskin

    Member
    May 27, 2021 at 8:29 pm

    @Pharma

    Thank you for the thoughts on this.  For interactions you answered what I was looking for.  My plan is to make a cream with about 10%-15% Progesterone.  This will not be labeled with any claims or intended use/dosage.  Can’t find much on the web beyond basic compounding formulas using stock base from PCCA.  

  • PhilGeis

    Member
    May 28, 2021 at 11:11 am

    Great comments from pharma.   

    chickenskin said:

    @Pharma

    Thank you for the thoughts on this.  For interactions you answered what I was looking for.  My plan is to make a cream with about 10%-15% Progesterone.  This will not be labeled with any claims or intended use/dosage.  Can’t find much on the web beyond basic compounding formulas using stock base from PCCA.  

    No claims?  Why are you using the stuff?  

  • chickenskin

    Member
    May 29, 2021 at 2:56 am

    @PhilGeis

    Personal project no intention on developing beyond personal use.