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Preservation
I want to know - in what percentage can phenoxyethanol and ethylhexylglycerin individually be used in a cream with pH 5.5?
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8 Replies
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Can and should are two different pairs of shoes. Can = anything you feel happy with and which doesn’t kill the product or the consumer; should = the amount needed to preserve your product sufficiently. Phenoxyethanol has a quite well defined recommended usage level. EHG has too but as a multifunctional booster, you can basically add as much as you want, just don’t go below a minimum.
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Look for data re. “Euxyl 9010” (90% phenoxy/10% ehg). EU directive allows to 1% Phenoxyethanol - suggest starting ~5000 ppm.
Think this leaves a gap re. fungi - might consdier IPBC or organic acid. -
Pharma said:Can and should are two different pairs of shoes. Can = anything you feel happy with and which doesn’t kill the product or the consumer; should = the amount needed to preserve your product sufficiently. Phenoxyethanol has a quite well defined recommended usage level. EHG has too but as a multifunctional booster, you can basically add as much as you want, just don’t go below a minimum.
What would be the ‘minimum’ for EHG?
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They already told you. %0.1 EHG with % 0.9 phenoxyethanol
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EHG is said to be active above 0.1% as booster for example for phenoxyethanol. Alone, you’d have to use it well above 1%. Meaning, EHG in a blend like Euxyl 9010 will be limit if sticking to the EU regulation which @PhilGeis mentioned. Given that it’s not too problematic even at 5% or higher (contact allergies are infrequent but we will, most likely, see more in the future due to increasing usage of EHG) and it also acts as emollient and humectant, inclusion at more that just 0.1% seems reasonable. Compared to other, similar compounds, I’d aim at 0.3-0.5% or even more but be careful because higher levels might in some cases interfere with emulsion stability and/or viscosity.
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Pharma said:EHG is said to be active above 0.1% as booster for example for phenoxyethanol. Alone, you’d have to use it well above 1%. Meaning, EHG in a blend like Euxyl 9010 will be limit if sticking to the EU regulation which @PhilGeis mentioned. Given that it’s not too problematic even at 5% or higher (contact allergies are infrequent but we will, most likely, see more in the future due to increasing usage of EHG) and it also acts as emollient and humectant, inclusion at more that just 0.1% seems reasonable. Compared to other, similar compounds, I’d aim at 0.3-0.5% or even more but be careful because higher levels might in some cases interfere with emulsion stability and/or viscosity.
Thank you for your valuable input.
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Pharma said:EHG is said to be active above 0.1% as booster for example for phenoxyethanol. Alone, you’d have to use it well above 1%. Meaning, EHG in a blend like Euxyl 9010 will be limit if sticking to the EU regulation which @PhilGeis mentioned. Given that it’s not too problematic even at 5% or higher (contact allergies are infrequent but we will, most likely, see more in the future due to increasing usage of EHG) and it also acts as emollient and humectant, inclusion at more that just 0.1% seems reasonable. Compared to other, similar compounds, I’d aim at 0.3-0.5% or even more but be careful because higher levels might in some cases interfere with emulsion stability and/or viscosity.
If I were to
combine DMDM hydantoin and methyl paraben, would it make for a good,
broad-spectrum preservative? What percentage can I use the two at? Would I need
any additional preserving compounds? -
Sure - a formaldehyde releaser with parabens (and EDTA) was the classic combination late last century - tho typically methyl and propyl parabens. Try 2500 DMDM H with methyl propyl 2000/1000 ppm.
If you’re marketing in EU be aware of free formaldehyde limits.
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