Home Cosmetic Science Talk Formulating Polysorbate 80 and phenoxythanol

  • Polysorbate 80 and phenoxythanol

    Posted by Twish on January 2, 2021 at 5:17 am

    Hello everyone.
    Am new here and new to formulating, so please excuse any dumb questions.
    Would like to know if phenoxyethanol can be used as a preservative for a product that contains polysorbate 80. 
    I read that it destabilizes phenoxyethanol but I have seen quite a few products with the two together.
    Looking forward to your reply

    Twish replied 3 years, 5 months ago 4 Members · 7 Replies
  • 7 Replies
  • PhilGeis

    January 2, 2021 at 12:01 pm

    Concentration and formula dependent.  

  • Twish

    January 2, 2021 at 1:13 pm

    Thank you! I shall make a stable formulation and return for more advice. :)

  • Pharma

    January 2, 2021 at 3:55 pm
    The issue is not a ‘stable’ formulation with regard to physical stability but microbial stability ;) .
    If you want to play on the safer side, use ‘solvents’ such as glycols in your water phase to force phenoxyethanol out of the interface (i.e. the PEG-shell around the emulsion droplets). This however is not an exact science and glycols also tend to sit around the interphase… only a challenge test will tell if you’re on the right or wrong track.
  • Twish

    January 3, 2021 at 3:08 am

    Wow.. there is so much to learn here! With stable formula, I meant, I was still struggling with the physical stability of it. :D Thought I should get that right and then look into the preservative system.

  • Twish

    January 3, 2021 at 3:11 am

    And since I have only purchased phenoxyethanol, I was hoping it would work in all formulas..but I realize that’s not going to happen.

  • MetalizeMerz

    January 4, 2021 at 7:35 am

    With my product and my experience, they can work well together.

  • Twish

    January 6, 2021 at 2:16 am

    Oh! That is encouraging  :)

Log in to reply.