Home Cosmetic Science Talk Formulating Advanced Questions Literature suggestions on Ascorbic Acid/Vitamin C oxidation

  • Literature suggestions on Ascorbic Acid/Vitamin C oxidation

    Posted by Rafacasti on May 3, 2022 at 7:35 pm

    Hi guys! I’m doing some research on ascorbic acid/vitamin C oxidation. Does anyone have any suggestions in the literature to share?

    When I search I hardly find content about the oxidation of the acid itself and when I do I’m a little bit afraid to be trusting in studies that aren’t very reliable (or are outdated), so I’m asking you because you have more experience than me on this topic (I’m not a chemist :D ).

    Some examples that I found:

    • Shen, J., Griffiths, P.T., Campbell, S.J. et al. Ascorbate oxidation by iron, copper and reactive oxygen species: review, model development, and derivation of key rate constants. Sci Rep 11, 7417 (2021). https://doi.org/10.1038/s41598-021-86477-8
    • Tuğba Akbıyık , İnci Sönmezoğlu , Kubilay Güçlü , İzzet Tor & Reşat Apak
      (2012) Protection of Ascorbic Acid from Copper(II)−Catalyzed Oxidative Degradation in the
      Presence of Fruit Acids: Citric, Oxalic, Tartaric, Malic, Malonic, and Fumaric Acids, International
      Journal of Food Properties, 15:2, 398-411, DOI: 10.1080/10942912.2010.487630

    • M. Yussif, N. (2019). Vitamin C. Vitamin C - an Update on Current Uses and Functions. doi:10.5772/intechopen.81783

    I’m looking for any suggestions (from books to articles) to complement these ones. Thank you in advance!

    Rafacasti replied 2 years ago 3 Members · 4 Replies
  • 4 Replies
  • OldPerry

    May 3, 2022 at 7:46 pm

    What questions about Vitamin C oxidation are you trying to find answers to?

  • Rafacasti

    May 3, 2022 at 8:25 pm

    Perry said:

    What questions about Vitamin C oxidation are you trying to find answers to?

    You got me :D … I think I’m first trying to build a background on the subject to be able to better answer cosmetic questions. 
    At the chemical level:
    • What conditions are necessary for the reaction to occur?
    • Why is the molecule so unstable?
    • Can other reactions be triggered by oxidation?
    • The darkening is due to what reason?
    • What happens (on the skin) after oxidation?
    On a cosmetic level:
    • What happens in the product? Does it contribute to instability?
    • Why are water vehicles especially more sensitive than silicones?
    • Using the oxidized vitamin will not lead to cosmetic effects, but would it in itself be harmful to apply this product to the skin after darkening?
    In fact, I don’t know how much of it really helps me with what I need, but I end up feeling more comfortable when I understand the subject beforehand (chemistry before cosmetology, in this case). I can answer some of the chemical questions myself because of my biology background, but I think I’m looking for something more specific so that I can look for cosmetic references directly later (I ended up choosing to ask for suggestions instead of asking these questions directly because I didn’t want to ask too much :sweat_smile: ).
    When I’m asked to do research at work I always think “if I were to teach someone from the start who doesn’t know anything about this subject, where would I start?” and then there I go 
  • Pharma

    May 5, 2022 at 4:43 am
    Maybe start with something like THESE first or even THAT? At least, those options would allow you to answer some of the questions in above post which an article on ascorbic acid degradation likely won’t.
  • Rafacasti

    May 5, 2022 at 11:46 am

    @Pharma Thanks for your book recommendations! I only had contact with Lehninger during graduation, so I think it will diversify my knowledge a lot (organic chemistry really wasn’t a big thing in my course, everything I know came from high school and individual studies). Thanks also for the course recommendations.

    Have a good day!  :)

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