Home Cosmetic Science Talk Formulating improving solubility of ingredients


  • improving solubility of ingredients

    Posted by francisa on February 19, 2021 at 11:13 pm


    I am formulating a scalp treatment which will include biotin and vitamin b3….what ingredients do you recommend I incorporate to increase the solubility of those ingredients? 

    francisa replied 2 years, 9 months ago 2 Members · 2 Replies
  • 2 Replies
  • pharma

    February 20, 2021 at 6:52 pm
    For niacinamide, water works very well.
    To increase solubility of biotin (<0.02% in water), you may increase pH (turning it into it’s better water soluble salt form) using a base such as ethanolamine or use alcohol (solubility of 0.08%) or DMSO (4.9%) as solvent. Still, biotin solubility is generally poor in aqueous solutions at room temperature (if not in salt form) and that’s the reason why better soluble PEG derivatives and other esters/amides have been synthesised. Given that biotin is not soluble in oils, incorporating it as an emulsion is out of question. Using biotin based ionic liquids doesn’t work either if you have water in your product. You might try to adsorb biotin to zeolithe or silica and incorporate that…
  • francisa

    February 21, 2021 at 3:19 am

    thank you so much for such a thorough response! 

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