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Home Cosmetic Science Talk Formulating Hyaluronate + Niacinamide Serum Brown Discoloration

  • Hyaluronate + Niacinamide Serum Brown Discoloration

    Posted by drsimranjit_lv on October 3, 2022 at 12:16 pm

    INCI                                                                                           Percentage

    Aqua 53
    Niacinamide 10
    Sodium Hyaluronate Crosspolymer (and) Sodium Hyaluronate (and) Sodium Acetylated Hyaluronate (and) Hydrolyzed Sodium Hyaluronate (and) Pentylene Glycol (and) Ethylhexylglycerin (and) Aqua 5
    Snail Mucin Filtrate 5
    Saccharide Isomerate 3
    Xylitylglucoside (and) Anhydroxylitol (and) Xylitol 2
    Glycerin 2
    Butylene Glycol (and) Aqua (and) Acetyl Hexapeptide-37 2
    Aqua (and) Honey (and) Phospholipids (and) Sphingolipids (and) Hyaluronic Acid 1
    Glycereth-26 1
    Methyl Gluceth-20 1
    Magnesium Aspartate (and) Zinc Gluconate (and) Copper Gluconate 1
    Sodium PCA 1
    Bis-PEG-18 Methyl Ether Dimethyl Silane 1
    Phenoxyethanol (and) Benzoic Acid (and) Dehydroacetic Acid 0.8
    Pentylene Glycol 0.5
    Water (Aqua) (and) Glycerin (and) Hedera Helix (Ivy) Leaf Extract (and) Arnica Montana Flower Extract (and) Sambucus Nigra Flower Extract (and) Malva Sylvestris (Mallow) Flower Extract (and) Tilia Platyphyllos Flower Extract (and) Cucumis Sativus (Cucumber) Fruit (and) Parietaria Officinalis Extract (and) Sodium Benzoate (and) Potassium Sorbate 0.5
    Laminaria Saccharina Extract 0.5
    Biosaccharide Gum-1 0.5
    D-Panthenol 0.1
    Disodium EDTA 0.1
    Propanediol 5
    Ethoxydiglycol 3
    Hydrolysed Sodium Hyaluronate 0.5
    Hydrolysed Sodium Hyaluronate 0.5
    Sodium Hyaluronate 0.2

    pH = 6

    This is the formulation for a Hyaluronic Acid + Niacinamide Serum which is turning yellow to brown with time. Also Haziness is increasing. Please suggest changes.

    imanebouziane replied 6 months, 3 weeks ago 6 Members · 5 Replies
  • 5 Replies
  • gbrizius

    October 3, 2022 at 11:19 pm

    If there is any Vitamin C in the botanicals, it can react over time to form a yellowish complex with the niacinamide.  AFAIK it doesn’t change the effectiveness of either ingredient, it’s just a charge-transfer coloration

  • Graillotion

    October 3, 2022 at 11:49 pm

    You have so many ingredients….doing a knock-out is gonna take a while.  But I’d probably start with the one that has copper.

  • melissasweiss

    October 18, 2022 at 1:26 pm

    I am having the same issue!  RAised PH to 6.5 and still browning

     Organic Aloe (Vera) Barbadensis Leaf Juice,
    Dead Sea Magnesium Oil, Sodium Hyaluronate, Niacinamide (Vitamin B3),
    Propanediol (Natural) & Hydroxyacetophenone.
  • Microformulation

    Professional Chemist / Formulator
    October 18, 2022 at 4:33 pm
    Organic this, natural this and that, and then a non-approved preservative under many standards. What is your marketing?

  • imanebouziane

    November 2, 2022 at 6:15 pm

    Microformulation pourriez vous nous expliquer pourquoi le conservateur est non approuv√©