Home Cosmetic Science Talk Formulating How to work with Palmitoylethanolamide?

  • How to work with Palmitoylethanolamide?

    Posted by granmasutensil on January 3, 2019 at 11:17 am

    Sometimes referred to as PEA,
    although there is another compound with the same abbreviation. It’s a quite effective, very safe(since the body already makes it), multi
    beneficial compound. Especially when it comes to skin irritation and
    inflammation. It normalizes a huge amount of genes in the body also
    which lends to it’s many potential benefits. It’s used mostly clinically
    but anyone can buy a topical of it. It’s just few companies make it, and the
    price is extremely inflated, especially considering use for body
    application. There are almost no topical products with it I assume due
    to it’s very poor solubility something like 6mg a ml in ethanol for
    example, and it’s high
    melting point of around 93-98 C.

    What
    I’ve tried is putting it in some jojoba oil which has very good heat
    stability and heating it up, liquefying the Palmitoylethanolamide in the
    jojoba. Then immediately stick blending it into a lotion since it
    resolidifies extremely fast. Maybe it wouldn’t with more jojoba oil used
    but I don’t want a lot of jojoba in the final product. Any thoughts or
    ideas on other methods, or changes to improve what I’m already doing?
    Thank you

    gunther replied 5 years, 1 month ago 3 Members · 2 Replies
  • 2 Replies
  • chemicalmatt

    Member
    January 4, 2019 at 4:49 pm

    You are going to need a surfactant to keep that amide from recrystallizing even though PEA is a polar molecule. Without knowing your formula application or parameters, a little lecithin should prevent that from happening, but after that…..????

  • gunther

    Member
    January 5, 2019 at 1:37 am

    I wonder if Polysorbate 60 and sorbitan stearate help dissolving palmitoylethanolamide, in this formulation
    https://vitalitus.com/product/soothamide/

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