Home Cosmetic Science Talk Formulating How to work with Palmitoylethanolamide?

  • How to work with Palmitoylethanolamide?

    Posted by granmasutensil on January 3, 2019 at 11:17 am

    Sometimes referred to as PEA,
    although there is another compound with the same abbreviation. It’s a quite effective, very safe(since the body already makes it), multi
    beneficial compound. Especially when it comes to skin irritation and
    inflammation. It normalizes a huge amount of genes in the body also
    which lends to it’s many potential benefits. It’s used mostly clinically
    but anyone can buy a topical of it. It’s just few companies make it, and the
    price is extremely inflated, especially considering use for body
    application. There are almost no topical products with it I assume due
    to it’s very poor solubility something like 6mg a ml in ethanol for
    example, and it’s high
    melting point of around 93-98 C.

    I’ve tried is putting it in some jojoba oil which has very good heat
    stability and heating it up, liquefying the Palmitoylethanolamide in the
    jojoba. Then immediately stick blending it into a lotion since it
    resolidifies extremely fast. Maybe it wouldn’t with more jojoba oil used
    but I don’t want a lot of jojoba in the final product. Any thoughts or
    ideas on other methods, or changes to improve what I’m already doing?
    Thank you

    gunther replied 5 years, 1 month ago 3 Members · 2 Replies
  • 2 Replies
  • chemicalmatt

    January 4, 2019 at 4:49 pm

    You are going to need a surfactant to keep that amide from recrystallizing even though PEA is a polar molecule. Without knowing your formula application or parameters, a little lecithin should prevent that from happening, but after that…..????

  • gunther

    January 5, 2019 at 1:37 am

    I wonder if Polysorbate 60 and sorbitan stearate help dissolving palmitoylethanolamide, in this formulation

Log in to reply.