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How to work with Palmitoylethanolamide?
Sometimes referred to as PEA,
although there is another compound with the same abbreviation. It’s a quite effective, very safe(since the body already makes it), multi
beneficial compound. Especially when it comes to skin irritation and
inflammation. It normalizes a huge amount of genes in the body also
which lends to it’s many potential benefits. It’s used mostly clinically
but anyone can buy a topical of it. It’s just few companies make it, and the
price is extremely inflated, especially considering use for body
application. There are almost no topical products with it I assume due
to it’s very poor solubility something like 6mg a ml in ethanol for
example, and it’s high
melting point of around 93-98 C.What
I’ve tried is putting it in some jojoba oil which has very good heat
stability and heating it up, liquefying the Palmitoylethanolamide in the
jojoba. Then immediately stick blending it into a lotion since it
resolidifies extremely fast. Maybe it wouldn’t with more jojoba oil used
but I don’t want a lot of jojoba in the final product. Any thoughts or
ideas on other methods, or changes to improve what I’m already doing?
Thank you -
2 Replies
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You are going to need a surfactant to keep that amide from recrystallizing even though PEA is a polar molecule. Without knowing your formula application or parameters, a little lecithin should prevent that from happening, but after that…..????
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I wonder if Polysorbate 60 and sorbitan stearate help dissolving palmitoylethanolamide, in this formulation
https://vitalitus.com/product/soothamide/
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