Home Cosmetic Science Talk Formulating Homogenizers vs High Speed Immersion Blenders - is there a practical difference?

  • Homogenizers vs High Speed Immersion Blenders - is there a practical difference?

    Posted by zink on July 14, 2016 at 5:00 am

    I’m looking at some formulas using various zinc oxide dispersion from DOW, Kobo and Umicore primarily. Interestingly their sample formulas suggest anything from just paddle mixing to homogenization for 3 minutes or until “desired particle size has been reached” (assuming you have access to a scanning electron microscope to make sure you’re where you want to be).

    I’m wondering, for bench test formulation, can your typical 12000 rpm immersion blender provide the same ability to break up and evenly disperse agglomerated mineral particles as your typical 20000 rpm homogenizer? It it mostly a function of time, or is is there some qualitative difference between the methods?

    Then further down the line, what equipment does most OTC-ok CMOs use?

    zink replied 7 years, 8 months ago 2 Members · 2 Replies
  • 2 Replies
  • HonestChemist

    Member
    July 22, 2016 at 4:31 am

    A little clarification would be nice. At what scale are you making this? The difference between immersion blenders and Homogenizers is one of shear. Most immersion blenders use high speed to produce shear, but because this is typically done with a spinning blade shear levels are relatively low and dont work to well for scaling up. Homogenizers on the other hand don’t run quite as fast (typically 2000-5000 rpm) but they produce greater shear force by the fact that its a blade inside a cage that forces liquid through holes (kind of like putting your fist in the palm of your other hand and grinding. This action can force smaller particle sizes. This is also more scaleable as many homogenizers can be used “in-line” through a pump and hose that gets recirculated.

    Also due to the fact that the “particle size” that is being referenced in these procedures most likely is describing oil droplet particle size for creating stable emulsions, you can estimate this size by using a simple 100x light microscope. These can be purchased for as little as $250 on Amazon.

    If you are making small lab / hme batches an immersion blender should work fine. If you are paying a CMO to do the work ensure they have a homogenizer on hand.

  • zink

    Member
    July 23, 2016 at 3:03 am

    Thanks for the thorough response, this makes sense.

    I’m doing small scale test formulations, so in that case it’d seem a immersion blender could suffice. I do check with my CMOs regarding their equipment.

    As for particle size, what intersts me is mainly pigment particle size, either for color cosmetics or sunscreen formulation - would e.g https://www.amazon.com/AmScope-M160C-2L-PB10-E2-Magnification-Illumination-Battery-Powered/product-reviews/B00H7RMHTG/ref=cm_cr_dp_see_all_btm?ie=UTF8&showViewpoints=1&sortBy=recent be of any use for looking at emulsions with ZnO to see how big the particles agglomerates are?

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