Posted by Chemist77 on November 23, 2013 at 1:08 am

    Recently I had a supplier who said that the Hydrolyzed Glycosaminoglycans enhance the skin penetration and helps the actives to act in a much better and efficient manner. When I did a little research all I could found was that it basically is a good skin moisturizing agent and to some extent helps the retention of the same for longer periods, relatively. Is it really a fact that it can enhance the skin penetration for the proper efficacy of actives?????? 

    OldPerry replied 10 years, 6 months ago 3 Members · 3 Replies
  • 3 Replies
  • shawnhebert

    November 24, 2013 at 6:09 pm

    I’d love to hear any insights on this ingredient.  Years ago I worked for a company whos ‘claim to fame’ was cellular technology, claiming to use active skin cells in their product.  Not seeing skin cells in the ingredients list, I ask about it and was told it was the glycosaminoglycans.  Now, I’m no genius, but it’s not hard to figure out that GAGs are not skin cells, so I’ve always been curious as to what benefits they would offer in a cream.

  • Chemist77

    November 24, 2013 at 11:33 pm

    hyaluronic acid and mucopolysaccharides form the building blocks for the connective tissue (which for a layman could be claimed as cells) and HGAG is claimed to have the precursors for the mucopolysaccharides with high amount of hyaluronic acid monomer, hyalobiuronic acid. 

    This is a very basic explanation and I am not sure how precise it is but this is how I read it in suppliers’ literatures and other related material. 
  • OldPerry

    November 26, 2013 at 10:57 pm

    I doubt there are any studies that demonstrate HGAG can enhance skin penetration.  There aren’t many studies to show any topical treatment can enhance skin penetration without using something like a patch.

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