Home Cosmetic Science Talk Formulating HELP: Panthenol (B5) turning pink

  • HELP: Panthenol (B5) turning pink

    Posted by AbbieNorth on December 11, 2023 at 10:00 am

    I have made a b5 serum a few times now and it is turning pink after 24 hours. Why?

    chemicalmatt replied 1 year ago 4 Members · 5 Replies
  • 5 Replies
  • Perry44

    Administrator
    December 11, 2023 at 10:05 am

    Without a list of all the ingredients in your formula, it is difficult to give you any answer.

    My blind guess is that your product is contaminated with bacteria.

    • AbbieNorth

      Member
      December 11, 2023 at 10:14 am

      Simple formula:

      - HMW HA 1% with DI water

      - pantheon: I’ve tried both liquid and powder (d- and dl-) and it happens every time

      - euxyl K712

      No contamination, did mico tests on each batch Seems more like an oxidation? But this sent something that is document anywhere that I can find.

      • Perry44

        Administrator
        December 11, 2023 at 11:20 am

        Well, there are no obvious answers. However, I’d suggest you do a simple knock-out experiment to isolate which ingredient might be causing the problem. A knock-out experiment would simply be a series of batches each of which is missing one ingredient. You would replace the missing volume with water. So, if your batch normally calls for 1% HA, you would add 1% extra water instead. Then see which batch turns pink.

        It could be lots of things. Metal ions in your water, oxidation of ingredients, some unknown contamination in your ingredients, etc.

  • ozgirl

    Member
    December 11, 2023 at 4:10 pm

    Do you have a fragrance? Some fragrance components can can turn pink under certain conditions.

  • chemicalmatt

    Member
    December 12, 2023 at 7:57 am

    Whenever I hear of a drastic color change in something like this I look for the possible chromophore that would create that. In this case the aromatic benzoic acid comes to mind, otherwise…almost hate to suggest it…a nitrosamine (dangerous but colorful!) formed in combination with the amino functional group on panthenol? Hope not, but DEL the benzoate and see what happens.

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