Home Cosmetic Science Talk Formulating HA and peptide serum separating

  • HA and peptide serum separating

    Posted by Beginnnerformulator98 on March 25, 2024 at 12:40 pm

    Hi all, i’ve been using this formulation and i notice that after about 5 minutes the serum starts separating and has a water layer at the bottom with a froth-like white layer on the top. I also don’t know why this serum is white as opposed to the typical clear HA serums.


    Water- 86.5

    Ha- 0.25

    PGA- 0.25

    Dipropylene glycol- 5

    Allantoin- 0.4

    EDTA- 0.1

    1,2 hexadeniol- 1.5

    Matryxl 3000- 3

    Sodium hyaluronate crosspolymer- 0.5

    Sodium hyaluronate- 0.25

    Hydrolyzed sodium hyaluronate - 0.25

    Betaine- 2

    Hydrolyzed collagen- 0.25

    jemolian replied 1 week, 6 days ago 3 Members · 2 Replies
  • 2 Replies
  • chemicalmatt

    April 8, 2024 at 1:15 pm

    What’s with all those hyaluronate species? Must be one helluva’ hyaluronic salesperson calling on you there. You need to be more specific in your composition. Is that “PGA” polyglutamic acid? If so it is redundant with those many HA’s. What is meant by “betaine”? If it is true betaine (trimethylglycine) that may be your problem as it may be complexing with that HA crosspolymer. Remember “less is more” as Buckminster Fuller said.

  • jemolian

    April 8, 2024 at 7:50 pm

    What is the process you used to make this, what is the batch size and the tools used?

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