• Formulating

  GABA

  Posted by Cindy on March 2, 2016 at 4:58 pm

  I’m looking for information on using GABA in a formula. Its apparent activity is to relax muscles like botox. I was looking for any scientific information on using GABA topically, as well as potential side effects and concentrations. I’m coming up with nothing. Has anyone seen info or know where I can find info on GABA topically?

  gfeldman replied 8 years, 2 months ago 5 Members · 6 Replies
• 6 Replies

• 

  Bobzchemist

  Member

  March 2, 2016 at 7:44 pm

  By its effect, this would be a drug product, requiring a NDA. I have to strongly recomend against using it at all.

• 

  belassi

  Member

  March 2, 2016 at 10:52 pm

  I looked at most of what was available online and did not interpret it as “to relax muscles like botox”. If you’re in the USA then I agree with what Bob said. Secondly, a topical application is extremely unlikely to get below the derma and into the muscles. Don’t you think?

• 

  Cindy

  Member

  March 3, 2016 at 4:20 am

  Yes, I think its unlikely Belassi. However, I know a dermatologist who uses it and says it works great. So I am just trying to dig up more information on it and can’t seem to find any, especially when it comes to safety. I worry that a side effect of ‘relaxing muscles’ could be saggy skin.

• 

  belassi

  Member

  March 3, 2016 at 5:01 am

  It is a substance that’s readily available so if you learn more it could be very interesting. There is already a ‘vegetable botox’ available but it costs a pretty penny.

• 

  Mike_M

  Member

  March 3, 2016 at 2:15 pm

  Check into sports performance literature to get a comprehensive view. This has been around a while in that field. You’ll find plenty of stuff that isn’t useful but typing it into your search index a little differently could yield more useful information.

• 

  gfeldman

  Member

  March 3, 2016 at 4:23 pm

  According to the PCPC Aminobutyric Acid (gaba) is readily available and is considered a skin conditioning agent. Not only that, there is reliable literature on pubmed indicating that it may be effective. Goes without saying, but I would suggest not claiming this effectiveness (as a fact) on your product (aka not a drug).

  J Invest Dermatol. 2002 Nov;119(5):1041-7.gamma-Aminobutyric
  acid (A) receptor agonists accelerate cutaneous barrier recovery and
  prevent epidermal hyperplasia induced by barrier disruption.Denda M¹, Inoue K, Inomata S, Denda S.

  “These results suggest that the gamma-aminobutyric acid (A)-like receptor
  is associated with skin barrier homeostasis and regulation of the
  receptor clinically effective for barrier dysfunctional or epidermal
  hyperproliferative diseases.”

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