• Formulating

  Formulating with Sensitive actives

  Posted by drsimranjit_lv on February 1, 2022 at 9:56 am

  I am formulating a hyperpigmentation cream using photosensitive actives like Sabiwhite, Pterowhite, Lumiskin, etc. which advise using photostabilisers and adding in the cold phase under 25ºC. What is the best method to add these ingredients in an emulsion while maintaining the activity of the active and ensuring maximum formulation stability. 

  drsimranjit_lv replied 2 years, 2 months ago 3 Members · 3 Replies

  • blending
  • emulsifier
  • emulsion
  • equipment
  • stability
• 3 Replies

• 

  CedarS

  Member

  February 1, 2022 at 1:10 pm

  Have you talked to the suppliers of these actives? I’ve gotten excellent technical advice by reaching out with questions like these. 

• 

  Paprik

  Member

  February 3, 2022 at 6:01 pm

  Yeah, as @CedarS said. 
  Check with supplier or get their datasheets. You should get all the information from there. How to incorporate into formula, how much, in-vivo efficacy data (for claims) and some formulation tips and more. 

  Some actives are heat sensitive, so you add them <40°C. Some of them are added to oil phase and heated to 80°C, etc. It really depends. 

• 

  drsimranjit_lv

  Member

  February 11, 2022 at 9:22 am

  I will do that, thanks @paprik and @cedarS

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