Home Cosmetic Science Talk Formulating General Off Topic Farnesol vs Hydrogenated Farnesene, in relation to possible allergen?

  • Farnesol vs Hydrogenated Farnesene, in relation to possible allergen?

    Posted by graillotion on January 24, 2022 at 5:52 am

    I am aware Farnesol is a possible allergen…. Does anyone know if the allergen is still intact when it is hydrogenated Farnesene?

    This is all asked under the auspices of a deodorant project.  So naturally one would also want to know…. is one a more effective bacteriostat than the other? 

    graillotion replied 2 years, 1 month ago 2 Members · 3 Replies
  • 3 Replies
  • pharma

    Member
    January 24, 2022 at 7:51 pm

    The allergenic potential arises from the high degree of unsaturation, particularly the double bond in the 2,3 position with regard to the alcohol. Saturation removes all (in cosmetic quality maybe just most) those double bonds rendering the molecule to a branched fatty alcohol with about the same allergenic potential as those. As an educated guess, hexahydrofarnesol aka hydrogenated farnesol is likely not or only margianlly active against microbes and in the same pot as the emollient ‘iso-esters’ you’ve been researching.

  • graillotion

    Member
    January 25, 2022 at 4:44 am

    Pharma said:

    The allergenic potential arises from the high degree of unsaturation, particularly the double bond in the 2,3 position with regard to the alcohol. Saturation removes all (in cosmetic quality maybe just most) those double bonds rendering the molecule to a branched fatty alcohol with about the same allergenic potential as those. As an educated guess, hexahydrofarnesol aka hydrogenated farnesol is likely not or only margianlly active against microbes and in the same pot as the emollient ‘iso-esters’ you’ve been researching.

    Thank you, your brilliance is always welcome.  May many mac nuts find their way to Switzerland! (Last time I checked….some were on the way, along with some squalane wax and Himalayan Cedar EO  :D )

  • graillotion

    Member
    January 25, 2022 at 5:07 am

    Farnesol will become a distant memory.

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