Home Cosmetic Science Talk Formulating farnesol a big issue?

  • farnesol a big issue?

    Posted by natiyo123 on October 10, 2022 at 2:42 pm

    hello

    im using farnesol as a deo active at 0.3% concentration in the final product, IFRA limit is 0.062%

    My question is, does it in real life really affect consumers? would users really be experiencing an allergy to my product? so far I havent received any complaint but I dont know if I should just replace it with something else

    also can you suggest aroma chemicals with antimicrobial properties
    Im considering thymol and phenethyl alcohol

    other EOs I have tried havent worked so well even at 1%: peppermint, lavender, clove, etc. 

    Pharma replied 1 year, 6 months ago 5 Members · 8 Replies
  • 8 Replies
  • Graillotion

    Member
    October 10, 2022 at 6:40 pm

    As with any allergen, some will have a response, and many will not.  You can create the same result with ingredients that have a lower chance of an allergic response.

    You just decide how many responses are acceptable and formulate with that in mind.

  • OldPerry

    Member
    October 10, 2022 at 6:57 pm

    If IFRA says don’t use the amount you’re using, you should follow that guideline. At least in the US, if they believe your product harmed them they would point to the fact that you are using an ingredient outside the safety limits of a respected organization.

  • natiyo123

    Member
    October 11, 2022 at 9:05 am

    As with any allergen, some will have a response, and many will not.  You can create the same result with ingredients that have a lower chance of an allergic response.

    You just decide how many responses are acceptable and formulate with that in mind.

    can you suggest some of these ingredients?

  • gordof

    Member
    October 11, 2022 at 10:46 am

    the main deodorant ingredients are ZInc Ricinolat and Antimicrobial Raw Materials like Sodium Caproyl/Lauroyl Lactylate

    I would always go with zinc Ricinolate because it has a Scent absorption/binding activity and does not harm the Microbiome of the skin. 

    Of course, you can just use some Other not so Allergic Perfum to cover the negative scent depending on the time you want the deodorant to be tested.

    There is the possibility of using Triethylcitrat which is deactivating the deconstruction of sweat and therefore eliminates ba d scent as well.  

    Combination of different areas, for example, Decalact Deo  (Sodium Caproyl/Lauroyl Lactylate, Triethyl Citrate, Salvia Officinalis (Sage) Oil) are very helpful if you don’t want to eliminate only one threat.

  • Pharma

    Member
    October 11, 2022 at 7:05 pm

    In vitro data suggest that 0.062% farnesol is more than enough (especially if combined with other antimicrobial ingredients). True, preservatives and deodorising ingredients are usually used at many times higher concentrations than what’s needed in vitro but 0.062% is already >3 times higher than the highest one I could find in a quick&dirty google search.

  • Graillotion

    Member
    October 11, 2022 at 8:47 pm

    natiyo123 said:

    can you suggest some of these ingredients?

    Does your formula contain water?  This will determine some of what can be used.

    The decalact deo from Evonik mentioned above is a good addition, but for me…is not a ‘stand alone’.  If you live in the US….it is sold by FSS.

    Are you formulating a high pH deo, or low pH deo….this of course will also determine what you can pair.

  • natiyo123

    Member
    October 12, 2022 at 9:17 am

    Gordof said:

    the main deodorant ingredients are ZInc Ricinolat and Antimicrobial Raw Materials like Sodium Caproyl/Lauroyl Lactylate

    I would always go with zinc Ricinolate because it has a Scent absorption/binding activity and does not harm the Microbiome of the skin. 

    Of course, you can just use some Other not so Allergic Perfum to cover the negative scent depending on the time you want the deodorant to be tested.

    There is the possibility of using Triethylcitrat which is deactivating the deconstruction of sweat and therefore eliminates ba d scent as well.  

    Combination of different areas, for example, Decalact Deo  (Sodium Caproyl/Lauroyl Lactylate, Triethyl Citrate, Salvia Officinalis (Sage) Oil) are very helpful if you don’t want to eliminate only one threat.

    thanks, all of these are good ideas…  I should have mentioned from the start my formula… my actives are TEC, glyceryl Caprylate, Glyceryl Undecylenate and ethyl hexyl glycerin
    but I still wanted to add another layer of protection with antimicrobial aroma chemicals… I want to make a very potent formula because I live in a tropical country. I have never tried zinc ricin. I should give it a try!

  • Pharma

    Member
    October 12, 2022 at 12:15 pm

    I don’t know how good an antimicrobial farnesol actually is. Literature suggests that it’s mostly a quorum sensing molecule which stops yeast from switching into the hyphen form and bacteria from building biofilms. Both are not (should not be) an issue with cosmetics and play no role in malodour.

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