Home Cosmetic Science Talk Formulating Dosing from in Vitro to In Vivo

  • Dosing from in Vitro to In Vivo

    Posted by Joejoe on September 25, 2023 at 4:13 am

    Hi all,

    We have in vitro studies of an ingredient. From the efficacy view, we cannot use the same concentration that we used in vitro. How do you convert in vitro concentration to in vivo (human) for skincare products? Is there any guidelines? How is your experience? Thanks



    Perry44 replied 8 months ago 2 Members · 1 Reply
  • 1 Reply
  • Perry44

    September 25, 2023 at 7:46 am

    I suppose that depends on the claims you want to make. Let’s look at an example.

    Suppose you have an in vitro experiment that shows active X at 2% gives some benefit. Well if you want to claim that benefit in your product you should use it at 2% in your formula. At least you could make an argument it really could deliver that benefit.

    In truth, you should really test in vivo from your formula at the % actually used if you want to make the claim.

    But if you word your claim in the right way, you can put a tiny fraction of the ingredient in the final formula and simply imply that it will deliver some claim.

    But it would help if we had more information about the ingredient/benefit you are trying to deliver.

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