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Disinfectant
Hi. Can you help me? I am formulating a disinfectant with guava extract , centella asiatica extract and aloe vera extract. I noticed that when I add more ethanol, the solution became clear. My worry is how much ethanol is too much for wound disinfectant since we all know that when alcohol is added to wounds, it stings. Thank you so much.
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11 Replies
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Is this for personal use or to be marketed - and in what country?
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We will market it here in the Philippines.
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You should check Philippine regs.
60-95% is the typical range - but please be aware the aloe and guava may screw up your efficacy.
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Hello.
As Phil mentioned, check your country’s regulation and take your other ingredients under consideration, as they may reduce the efficacy of your product . Otherwise, this may be useful: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132458/
but there are plenty more articles on this topic.
Higher concentrations usually sting when applied to a wound, but you probably need higher content of ethanol for proper efficacy, if this is the only desinfectant in your formula.
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Any update?
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Hmm. I guess I didn’t explain well my questions. Because the active raw material in this formulation is guava extract, centella extract and aloe vera extract. Ethanol is just a solvent. So I am also wondering if this product will be used as wound disinfectant. For a short background, this product already has formulation and I was just trying to improve its appearance however the previous formulator only had 1% ethanol and my formulation now has 5% ethanol. So I didn’t know if that was too much.
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As a “disinfectant” - antiseptic, ethanol is an active. How/to what action/efficacy are guava extract, centella extract and aloe vera extract “actives”?
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In the philippines, back in the old age people are using guava leaves to disinfect wounds. You can also read various articles about the efficacy of guava extract in treating wounds as well as centella asiatica, and aloe vera.
https://journaljpri.com/index.php/JPRI/article/view/1882
https://www.medicalnewstoday.com/articles/centella-asiatica-for-skin
https://www.webmd.com/diet/supplement-guide-aloe-vera
journaljpri.com
Wound Healing Efficacy of Guava Leaf Extract | Journal of Pharmaceutical Research International
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas of pharmaceutical Science including pharmaceutical drugs, community pharmacy, hospital pharmacy, clinical pharmacy, compounding pharmacy, consultant pharmacy, internet pharmacy, veterinary pharmacy, nuclear pharmacy, military … Continue reading
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PLEASE - read this stuff carefully before accepting it’s BS.
The guava article is a classic example of garbage science published in a 3rd rate journal. Their protocol couldn’t tell the diff between Pov-Iodine and saline or likely anything, much less show something about guava extract. Everthing was the statistically the same so they concluded an “implied”a benefit for guava.
The other links are to verbage.
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Disinfectant?
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I agree with @PhilGeis . Choose carefuly your sources and read with critic eyes. That journal has a very low impact factor (ca. 0.1). This is not a perfect metric, but it will help you filter papers.
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