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Home Cosmetic Science Talk Formulating Curoxyl 42 - Any tips on using it?

  • Curoxyl 42 - Any tips on using it?

    Posted by KimberlyLars on November 3, 2021 at 7:33 pm

    Hello All,
    I was wondering if anyone has had success with this material? I’ve tried using it at the manufacturers guidelines with no success, especially at room temp. I got this material so it would be easier to use but it’s proving the opposite. 

      %
    DI Water 90.10
    Sepigel 305 3.00
    Curoxyl 42 2.50
    Glycerin 1.00
    Euxyl PE 9010 0.90
    Extract in water/BG 2.50

    I’ve also tried a similar formulation with Sepimax EMT 10/ Sepimax Zen.
    Any tips or advice are welcome! Thank you.

    amitvedakar replied 1 year, 2 months ago 9 Members · 16 Replies
  • 16 Replies
  • Abdullah

    Member
    November 4, 2021 at 12:15 pm

    Write the INCi names

  • chemicalmatt

    Member
    November 4, 2021 at 4:11 pm

    @KimberlyLars better make sure everything there is peroxide stable or you will be sorry. Sepigel 305? Which “Extract”?  

  • ketchito

    Member
    November 5, 2021 at 11:46 am

    @KimberlyLars As @chemicalmatt mentioned, you need to have materials resistant to peroxides, which not be the case with your current formula. If you want to make a gel, you can find some gelling agents that work well with oxidizing agents (like Carbopol 674 although, not sure if it’s approved for cosmetics). You could actually build a gel using surfactants. 

  • PhilGeis

    Member
    November 5, 2021 at 2:03 pm

    How will you address stability?

  • MarkBroussard

    Member
    November 5, 2021 at 2:21 pm

    Curoyl 42 is in a Carbomer base, if I recall.  So, your best bet is to use Carbomer as your gelling agent, but double check on that.

  • Microformulation

    Member
    November 5, 2021 at 5:12 pm
    Curoxyl 42 has an INCI name of Water and Benzoyl Peroxide. There is a very good guiding document available for download here; https://www.ulprospector.com/en/na/PersonalCare/Detail/705/217985/Curoxyl-42?st=1
    Off-hand and from experience, you will likely need a better emulsification system.
  • Microformulation

    Member
    November 5, 2021 at 5:20 pm
  • KimberlyLars

    Member
    November 11, 2021 at 4:51 pm

    For those asking for INCI names:
    Water
    90.10
    Polyacrylamide
    & C13-14 Isoparaffin & Laureth-7
    2.00
    Water (and)
    Benzoyl Peroxide
    2.50
    Polysorbate 20 1.50
    Phenoxyethanol
    (and) Ethylhexylglycerin
    0.90
    Extract in
    Butylene Glycol
    2.50
    Hydroxyethyl
    Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
    0.50
  • KimberlyLars

    Member
    November 11, 2021 at 4:53 pm

    @Microformulation thank you for the feedback. I found their formulation tips to be unhelpful as I did exactly as instructed with no success. Thank you for providing the sample formulation.

  • KimberlyLars

    Member
    November 11, 2021 at 4:54 pm

    PhilGeis said:

    How will you address stability?

    Typical stability with light, dark, 25°C, 40°C, 4°C, Freeze/Thaw

  • Microformulation

    Member
    November 11, 2021 at 5:08 pm

    @Microformulation thank you for the feedback. I found their formulation tips to be unhelpful as I did exactly as instructed with no success. Thank you for providing the sample formulation.

    I have used the product numerous times and have had no difficulty getting a homogeneous product with an overhead stirrer. (IKA Eurostar Digital).

  • PhilGeis

    Member
    November 12, 2021 at 10:00 am

    PhilGeis said:

    How will you address stability?

    Typical stability with light, dark, 25°C, 40°C, 4°C, Freeze/Thaw

    Curoxyl 42 as Benzoyl peroxide - I assume you’re including this as an anti-acne active.  How do propose its determine  its stability.  Be aware - if you’re in US -this will be a drug product.
    Also - don’t understand the apparent comparison tio Sepimax.

  • ketchito

    Member
    November 12, 2021 at 12:58 pm

    @KimberlyLars It’d be good also to check for initial and final peroxide content, since peroxides tend to degrade in aqueous media (pH can also accelerate degradation). 

  • Stanley

    Member
    November 12, 2021 at 4:32 pm

    isn’t this explosive?  

  • Microformulation

    Member
    November 12, 2021 at 5:02 pm

    Stanley said:

    isn’t this explosive?  

    No. Where did you get that?

  • amitvedakar

    Member
    November 13, 2021 at 8:43 am

    Stanley said:

    isn’t this explosive?  

    In pure Raw form it is. But market available form are 40% (aproxi).

  • amitvedakar

    Member
    November 13, 2021 at 9:05 am

    And I also think good quantity PG & EDTA also help.