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creating 15% azelaic acid gel
Need your advice as a starting formulator. I want to make a anti-acne gel with 15% azelaic acid. KNow already to use propylene glycol to dissolve but in wich ratio? Because higher rate is more stickyan drisk of kristalissation. Want a light feeling gel. not ticky and working on acne. Any advice in inputs and how to formulate? thank you sofie
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5 Replies
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Are you starting with a prescription strength formula as a starting formulator? 15% Azealic acid is beyond the cosmetics standards, it’s a drug.
Plus, it’s highly unstable with pH and heat dependency to perform well in a formula. Reduce it down to 5%, dissolve in glycerin or in propanediol as it’s a lot less sticky. You can try 1:2 ratio (5gr Azealic acid in 10 gr propanediol). Put them in a pre-gelled distilled water and stir. Try to keep it between the pH of 4.5 to 5, add preservative and chealating agents.
Again, if you’re a starter formulator, maybe start with a nice niacinamide lotion?
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Hello, i am formulating a cosmetic gel. I am EU based so non prescriptive under 20%. Want to put it in a liposome. Scientif research says optimal % to work on acne as from 15-20%. But if i want to put it in a liposome i don’t think i’ll need that high %. Any experience with liposomes?
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Lecithin (0.5% or less) is the way to create liposomes in formulas. Get a decent soy lecihthin and work with it.
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Thank you Onur!
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Thank you for this valuable post……….
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