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  Centrifugation as a stability standard for emulsions o/w

  Posted by Anonymous on February 4, 2019 at 5:25 pm

  Hi,

  How important is centrifugation of an emulsion to tests its stability? Is this test really worth investing in a centrifuge?

  If this test is important, what protocol is the best to follow? 3000 rpm for 30 minutes? 

  I will appreciate your help. 

  Thanks

  Gunther replied 5 years, 2 months ago 3 Members · 3 Replies

  • centrifuge
• 3 Replies

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  EVchem

  Member

  February 4, 2019 at 6:57 pm

  I would say there are other things you can do first that are lest costly/ good indicators of stability. Are you already monitoring samples in stability chambers over time? Do you use freeze/thaw testing?

  The centrifuge might be able to tell you about the emulsion strength, but the ovens/fridge are nice so you can see how your product will fare in some real-life temperatures over time. 

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  OldPerry

  Member

  February 4, 2019 at 7:20 pm

  Centrifuge is not an important part of stability testing. It might be useful for developing prototypes but the company I worked for never used centrifuges for stability testing.

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  Gunther

  Member

  February 4, 2019 at 8:23 pm

  I’m curious about it.
  No amount of centrifugation should make true solutions form precipitates.
  But I guess that precipitation may well happen with emulsions.

  If you have a lab centrifuge handy, you can start by testing commercial formulations by centrifuging for 2, 5, 7 ,10 minutes and so on.
  Keep us posted with the results.

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