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  Centrifugation as a stability standard for emulsions o/w

  Posted by Anonymous on February 4, 2019 at 5:25 pm

  Hi,

  How important is centrifugation of an emulsion to tests its stability? Is this test really worth investing in a centrifuge?

  If this test is important, what protocol is the best to follow? 3000 rpm for 30 minutes? 

  I will appreciate your help. 

  Thanks

  XYZ123 replied 4 days, 8 hours ago 5 Members · 4 Replies

  • centrifuge
• 4 Replies

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  EVchem

  Member

  February 4, 2019 at 6:57 pm

  I would say there are other things you can do first that are lest costly/ good indicators of stability. Are you already monitoring samples in stability chambers over time? Do you use freeze/thaw testing?

  The centrifuge might be able to tell you about the emulsion strength, but the ovens/fridge are nice so you can see how your product will fare in some real-life temperatures over time. 

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  OldPerry

  Professional Chemist / Formulator

  February 4, 2019 at 7:20 pm

  Centrifuge is not an important part of stability testing. It might be useful for developing prototypes but the company I worked for never used centrifuges for stability testing.

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    XYZ123

    Member

    April 18, 2025 at 12:59 am

    Hello Perry,

    In this case, do you think it is okay to go straight to freeze thaw testing and incubator testing directly to do the stability testing and it still should be fine?

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  Gunther

  Member

  February 4, 2019 at 8:23 pm

  I’m curious about it.
  No amount of centrifugation should make true solutions form precipitates.
  But I guess that precipitation may well happen with emulsions.

  If you have a lab centrifuge handy, you can start by testing commercial formulations by centrifuging for 2, 5, 7 ,10 minutes and so on.
  Keep us posted with the results.

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