Home Cosmetic Science Talk Formulating General Better humectant: urea or sodium lactate

  • Graillotion

    Member
    October 31, 2021 at 4:52 pm

    They work in different ways.

    Why choose.

    I use them both in the same product.

  • DaveStone

    Member
    November 1, 2021 at 1:26 am

    They work in different ways.

    Why choose.

    I use them both in the same product.

    How do they work differently? Which is molecularly smaller?

  • chemicalmatt

    Member
    November 4, 2021 at 3:30 pm

    Not so sure about humectancy and those two, since urea is generally used as a keratolytic. Place a 40% urea solution on your nail plate and overnight the nail will have dissolved and you’ll be ready for toe surgery.  Reason for using sodium lactate-lactic acid with high urea content is that is the best buffering system to stabilize urea at pH 5.0 - 5.5. Urea decomposes (reduces) into ammonia in aqueous solution - just ask any farmer who uses it for fertilizer.

  • DaveStone

    Member
    November 5, 2021 at 11:59 pm

    Not so sure about humectancy and those two, since urea is generally used as a keratolytic. Place a 40% urea solution on your nail plate and overnight the nail will have dissolved and you’ll be ready for toe surgery.  Reason for using sodium lactate-lactic acid with high urea content is that is the best buffering system to stabilize urea at pH 5.0 - 5.5. Urea decomposes (reduces) into ammonia in aqueous solution - just ask any farmer who uses it for fertilizer.

    Urea can dissolve healthy nail too? Or just fungal-infected nail?
    Isn’t sodium lactate keratolytic as well over 10%?
  • vitalys

    Member
    November 7, 2021 at 1:00 pm

    40% Urea is one of the strongest keratolytics, as @chemicalmatt mentioned, but at the concentration of 5-7% it becomes one of the most powerful humectants ( I would say the best one). 
    @DaveStone Yes, 40% Urea will dissolve a healthy nail too.

  • ngarayeva001

    Member
    November 7, 2021 at 11:24 pm

    I use sodium lactate on its own but I never use urea (in o/w) without sodium lactate (because buffer). As per my anecdotal experience nothing saves dry hands quicker than urea + sodium lactate.

  • OldPerry

    Member
    November 8, 2021 at 1:24 am

    @vitalys - better than glycerin? I doubt it

  • vitalys

    Member
    November 9, 2021 at 3:21 pm

    @Perry Actually, they are comparable in their effect, but still different. These two substances can apparently complement each other in different preparations. It also depends on a formulation and its purpose. However, there are plenty of formulations where Urea shows more pronounced and prolonged effect. For example, the special formulations for hand and foot care. I completely agree with @ngarayeva001 that urea is the best component to improve dry skin conditions. I can say the same about feet, atopic skin conditions, severe ichthyosis, hyperkeratosis, etc

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