Home Cosmetic Science Talk Formulating Azelaic acid solubility

  • Azelaic acid solubility

    Posted by Lmc on June 4, 2022 at 2:03 pm

    This is my first time working with azelaic acid ( 98 % ) flakes , tried dissolving in PG, Glycerine heated at 120 F but it recrystalized after it cooled down. I am trying to make a 10 % azelaic cream for acne . Not much information is out there thats helpful. Ethanol is out. I saw some people selling predissolved azelaic acid but that is not available where i stay. Also i feel like i am using too much PG and glycerine. Ratio 1:5:5. Please help

    Sofie replied 2 months, 3 weeks ago 3 Members · 3 Replies
  • 3 Replies
  • Bill_Toge

    June 5, 2022 at 9:13 pm
    the problem is that azelaic acid is both highly polar, and also contains a substantial carbon chain, so it’s soluble in very few solvents; what you need is an emulsion with a highly polar oil phase, e.g. a salicylate ester
    alternatively you could dissolve it in dimethyl formamide, but that’s very toxic by skin contact, so it’s not an option here
    • Sofie

      April 21, 2024 at 9:05 am

      Hi Bill, i have the same problem. Trying to make a 15% aza lotion. Can you provide me more information how to work this out in salicylate ester? thank you sofie

  • Lmc

    June 7, 2022 at 5:26 am

    @Bill_Toge thank you . Will try it out

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