Home Cosmetic Science Talk Formulating 70% glycolic solution

  • 70% glycolic solution

    Posted by AnnaUnce on November 13, 2020 at 11:44 pm

    Hey I’m very bad at math (I have dyscalculia) and I need help understanding the math behind getting a 5% or 10% addition to my formula with like a 70% solution or 80% solution. I just finished school but I still need help in this area. 

    ngarayeva001 replied 3 years, 6 months ago 5 Members · 6 Replies
  • 6 Replies
  • ngarayeva001

    Member
    November 14, 2020 at 11:01 pm

    X*.7=.05

  • biofm

    Member
    November 15, 2020 at 2:31 am

    Have you considered M1V1 = M2V2?  
    Using the the 70% solution and a 5% addition, your M1 is 70%, your M2 is 5%, and V2 is you total amount after mixing. Using those three numbers, you can calculate V1, the amount of 70% solution to be added.
    To get V1, multiply V2 by 5% and divide the answer you get by 70%.
    I hope this gives a rough estimate.

  • Dtdang

    Member
    November 15, 2020 at 11:40 am

    @ngarayeva001 & @biofm Just remind me the formula we learn the basic chemistry. But, it just calculate the concentration of glycolic acid. what formula is used to calculate the pH of 5% and 70%?

  • AnnaUnce

    Member
    November 18, 2020 at 4:58 am

    Sorry everyone. Thank you for these replies but I still don’t understand 

  • justaerin

    Member
    November 18, 2020 at 7:42 am
    I am not a chemist. I am not great at math. Maybe I can help.
    (Note: I am not suggesting that anyone do this, it is just an example on how I
    do the math. I am more comfortable using this incredibly roundabout way
    because it is simple and easy to remember how to do. I apologize to any
    chemists reading this. I know that it is especially bad because it is
    about an acid and the original version is probably a v/v not w/w
    solution.)
    Does it help to think of it as a solution where 1 arbitrary unit, like a gram, of this solution is 0.7 glycolic acid plus 0.3 water?
    So if you use 10 grams of this solution, 7 of that is glycolic acid and 3 is water.
    If you put 10 grams of this 70% glycolic solution into a bottle, and you add 90 grams of water to it, you’d have 7 grams of glycolic acid in 93 grams of water, or a 7% glycolic acid solution.
    If you needed some other amount of a 70% solution as an active percentage in the final product, say 5%, there’s probably a better way to do it, but what I do is get out a calculator and start putting in numbers. To get the active amount you take a number and multiply it by 0.7.
    So to get a 5% active solution from a 70% active solution, I started with 8 x 0.7, which is 5.6
    That’s too much, so then I tried 7.5 x 0.7 = 5.25
    Closer, but still too much so 7.25 x 0.7 = 5.075
    Ok, then 7.15 x 0.7 = 5.005
    If I really wanted to play it safe, 7.1 x 0.7 = 4.97
    So to make 100 grams of a 5% solution using a 70% solution, I’d use 7.15 grams of the 70% solution and 92.85 grams of water and end up with 5 grams of glycolic acid in 95 grams of water.
    This method works better with less scary ingredients. Like 70% sorbitol liquid.
    But I hope that it helps with the math or thinking about the math.
  • ngarayeva001

    Member
    November 18, 2020 at 12:22 pm

    @AnnaUnce, I think you might be overcomplicating it. To get 5% of active out of 70% solution you simply divide 0.05 to 0.7. To get 10% out of 80% solution you divide 0.1 to 0.8.

    x*concentration of your solution = % of the active ingredient in the formula.
    x*0.7=0.05
    x=0.05/0.7 = 7.14% of 70% solution is needed to achieve 5% concentration of active ingredient in the formula.

    Put it in  MS Excel for simplicity.

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