[PhilGeis]

Please speak in chemical names - not supplier terminology. Phenoxy/EHG with Benzoate and EDTA is reasonable. Why not use CMIT?

[PhilGeis]

Can you name the product?

[PhilGeis]

You do need some preservation

[PhilGeis]

The crappy odor is not something to mask - it indicates a stability issue you need to address

[PhilGeis]

Unfortunately MoCRA did not include the state preemption that brought support of the major companies and PCPC in the Feinstein-Collins senate bill.

Beware politicians, their posturing ignorance knows no bounds.

[PhilGeis]

Sure looks that way and no, major brands will not attempt to break our those 2 states.

FA releasers have lost market share for some time so prob. not a major impact.

[PhilGeis]

Incremental change will not buy much. Why can’t you use CMIT and EDTA?

[PhilGeis]

pH?

[PhilGeis]

What “antibac”? and why?

[PhilGeis]

<div>ATF indicates specific denatured alcohols for cosmetics.</div>

https://www.ecfr.gov/current/title-27/chapter-I/subchapter-A/part-21

See subpart D.

ecfr.gov

27 CFR Part 21 -- Formulas for Denatured Alcohol and Rum

27 CFR Part 21 -- Formulas for Denatured Alcohol and Rum

[PhilGeis]

Happi is a source of model formulas

[PhilGeis]

Gluconolactone hydrolyzes/breaks down spontaneously in solution to gluconic acid. Consider https://pubmed.ncbi.nlm.nih.gov/25043489/

Are you determining urea levels in stability testing?

[PhilGeis]

They also claim 5% “glycine” when they apparently mean glycerine.

[PhilGeis]

Benzoate is more effective in combination with surfactants and can be enough to pass USP 51. It is not enough to protect in use.

[PhilGeis]

attachment did not open so here are syllabi

First Semester

Module 1: Introduction to Microbiology (1/8-1/14)

Module 2: Sources of Microorganisms (1/15-1/21)

Module 3: Preservatives in Personal Care (1/22-1/28)

Module 4: Product Development Risk Assessments (1/29-2/4)

Module 5: Microbiology Laboratory Functions (2/5-2/11)

Module 6: Rapid Methods and Quality Control (2/12-2/18)

Module 7: Case Study and Midterm Exam (2/19-2/25)

Module 8: The Regulatory Environment (2/25-3/1)

Module 9: The Business Environment and Brand Equity (3/3-3/8)

Module 10: Leading Individuals and Teams (3/10-3/15)

Module 11: Case Study (3/17-3/22)

Module 12: Quality Assurance (3/24-3/29)

Module 13: Design and Risk Assessment (3/31-4/5)

Module 1: Introduction to the Course and Manufacturing Facilities Part 1 (5/6-5/12)

Second Semester

Module 1: Introduction to the Course and Manufacturing Facilities Part 1 (5/6-5/12)

Module 2: Manufacturing Facilities Part 2 and Clean Design Principles (5/13-5/19)

Module 3: Equipment Cleaning - the Chemistry and Effective Methods (5/20- 5/26)

Module 4: Equipment Cleaning - Validation and Case Study (5/27-6/2)

Module 5: CIP COP System application & Design, Hygienic Equipment Fabrication & Design (6/3-6/9)

Module 6: Surface Finishes and Concepts from Physics and their Application (6/10-6/16)

Module 7: Piping Schematics and Water System Part 1 (6/17-6/23)

Module 8: Material Review and Mid-term Exam (6/24-6/30)

Module 9: Water System Design, Testing and Validation (7/1-7/7)

Module 10: Good Manufacturing Practices & HVAC (7/8-7/14)

Module 11: Compressed Air and Environmental Monitoring Program (7/15-7/21)

Module 12: Micro Investigations, Case Studies and Hygienic Risk Assessment (7/22-7/28)

[PhilGeis]

benzyl alcohol and benzoate work in formula?

[PhilGeis]

Phenoxy with a questionable ester. Can you use EDTA? The gluconolactone (breaks down to gluconic acid) is not much.

Need something for fungi - what’s pH?

[PhilGeis]

What is your policy - FA releasers? parabens? “natural”?

[PhilGeis]

Would you please add a preservative

[PhilGeis]

Thanks, I see. Suppose parabens and IT’s are off the list too. oh well.

For leave ons (with lament for FA’s, i knew them well)

9010 with EDTA and benzyl, benzoate or DHA. Control pH. They can add sorbic with benzoic - some think it “synergistic” but I wonder at stability. If they need more efficacy, add glycols (cap or pent or both) at 1% or greater. Dave Steinberg insists antioxidant with benzyl but I don’t think that is a problem.

For surfactants and hair conditioners (with a lament for CMIT, another friend)

9010 with EDTA- and benzyl (for conditioner) and benzoate( for surfactant ) control the pH.

[PhilGeis]

Germall + but still a FA releaser. 9010 not much for fungi and weak vs Gram +

[PhilGeis]

Maybe that the stuff is another crap, patented preservative combination, bait for those eager to use a fake natural claim?

[PhilGeis]

Please Phil. Phenoxy and cap glycol are not natural , commercial sorbate is synthetic and formula 95%+ synthetic.

To your question - the levels you had should have worked and incremental increases are unlikely to make a difference. Please track down why you had apparent contamination - poor water quality, contaminated raw material, failed making hygiene, something.

[PhilGeis]

As a water in oil emulsion, product is not at risk for consumer contamination but you need too ensure the just need to ensure the “water soluble extract” as is won’t grow bugs.

Also, it’s likely to fail challenge testing so don’t bother, the test is meaningless here.

[PhilGeis]

The specific marketed product - are you referring to Latisse and similar Bimatoprost products? These are drugs specifically approved by FDA.