PhilGeis
Forum Replies Created
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As Perry said - this is unnecessary. I’ll add it’s BAD idea. Bacteria growing while you’re trying to “dry out”.
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Doubt crystals are hex glycol. It’s used in biotech to crystallize protein and other macromolecules.
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This is sodium hypochlorite, chlorine bleach, at acid pH - drop the pH too low and you have chlorine gas. It’s very reactive. The articles claiming effect refer to NaCl/process “stabilized” hypochlorous acid.
There are products marketed with the technology. Here’s one, it “removes” bacteria. Don’t think that would stand up well to potential FDA scrutiny - or ethics of many.
ebay.com
Wound Therapy, Hypochlorous Acid Safely Removes Bacteria So Wounds Can Heal, 8 O | eBay
A safe alternative to chlorohexidine, alcohol, and harsh antiseptics. TARGET BACTERIA: SkinSmart targets the #1 problem in chronic wounds—bacteria. Safely remove bacteria without irritating skin or wounds, or interfering with your skin’s natural healing process.
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Preservation seems over the top for an anhydrous product.
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Sodium Hydroxymethylglycinate - as 50% aq. solution ala Suttocide A. You’ll have a weakness vs fungi you may want to address and EDTA would be a good addition if your formula can take it..
Keep heat below 60C.
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Assume you’ve Phenonip or a similar preservation combination. This should be effective.
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Think you need a final formula, including preservative, before stability - unless you want to cycle mult. versions ands before expense of HRIPT. If it fails in PET fresh, it’ll be pointless to carry though stability - otherwise you may have a surprise with PET of 1st pull - a delay on product cycle. A new preservative system would prob have you repeat HRIPT.
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As ev noted, both have cap glycol and also include a lot of glycerine, maybe counting to some extent on Aw. What is packaging?
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This is BS!!
Search archive of posts. Better chance of death by meteorite.
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Parabens!
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Formulation has been reported to impact “effective” pKa of benzoic acid*, a phenomenon I’ve seen as efficacy in ~neutral pH shampoos.
*https://www.sofw.com/en/sofw-journal/articles-en/47-home-care/1703-enhancing-antimicrobial-efficacy-of-sodium-benzoate
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Wonder of just “100%” is enough
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maybe they thought e-wax meant ear wax.
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Has it passed challenge?
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Good perspective. To OP’s question
More hexanediol. I don’t see it in the ingredient list - to that, please use chemical or INCI names. Maybe missed a commercial name.
For shampoos/surfactants - rinse-off products, chloromethyl isothiazolinone is more traditional esp with EDTA and benzoate*. Phenoxy/EHG/Benzoate/EDTA is prob pretty effective. Unless you’ve resources to qualify a diol, suggest you not chase it.
* not for fungi, they rarely cause issues in surfactant products, but as co-preservative, esp. to mitigate adaptation to the primary. Na benzoate serves this well and is effective beyond it’s pKa when combined with many surfactants (i.e. demonstrable efficacy up to pH neutrality).
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You’ve CHA and piroctone is insoluble.
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Piroctone is waste as a preservative.
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3 weeks at 60C is BS. If that’s the only condition that causes the issue - then you have no issue. T
Some officious clown in your company has you guys wasting your time and energy for no benefit.
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Spot on. Many fungal treatments are based on siderophore - hydroxamate (ZPT) or hydroxamate like (Piroctone) structure. ZPT safety in use is partially due to its poor solubility - the highly soluble NaPT is fairly toxic. Mechanism is divalent cation binding that screws up functins like DNA synthesis and repair. Pharma mentions many other points.
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They clearly have no knowledge of the cosmetic industry - not ingredients, microbiology, preservatives, testing CIR, etc. They worked off MIC’s and hung efficacy confirmation on single applications in USP 51, but cut it back to only two of the bugs. No consideration of in-use or even understanding of the purpose of preservation.
They published a similar article in 2017 in the same journal claiming octyl gallate was the panacea.
Mentioned the 3G comedy as ongoing - when it closed out with failure years ago.
This kind of garbage adds fuel to the even more ignorant regulators and profoundly ignorant (esp. state) legislators giving us bans ala Wash state.
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3 weeks at 60C? This is excessive - relevance to real life long term aging is highly doubtful.
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good
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nominal 37% - an Aw prob. <0.9.
Does pantent mention preservation?
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how much water?
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Think you could do better than (just) organic acids - esp adding isothiazolinone esp. or even phenoxy