PhilGeis
Forum Replies Created
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is that ethanol?
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Phenethyl alcohol can migrate in to packaging and implements so be sure to get stability data with complete packaged product.
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dyes/color additives - https://www.fda.gov/industry/color-additives
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To test, no but any challenge in stability should use product aged in container and with any implement packaged in product (e.g. mascara brush)/.
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Pharma - micro data certainly support this phenomenon. Note preservation of shampoos - Pantene, Heads & Shoulders, Aussie, Herbal Essences
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yes
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As Pharma noted - sorbate/benzoate concetrations are too high - drop each by 50% - and you don’t need both. Suggest addition of phenoxyethanol.
In production, the water phase will grow microbes if you let it sit around.
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You’re marketing in EU? What are your chaolnege test stability data - assume in final market container?
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Look at SDS for current marketed products - e.g. https://www.msdsdigital.com/olay-moisturizing-lotion-msds
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Thanks. River Ganges! We acquired Indian Co. making a Ganga bar soap - not what you think - made with water from the river Ganges. QC estab specs for all raw materials and asked me what the micro spec should be - for the river water. No treatment allowed - this is a mystical product. Suggested “no visible floaters”
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Emotelle said:
So what pairs well with Euxyl PE9010 to boosts its preservation effectiveness? Do you all have something to recommend?
What’s the product?
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Be careful with “Hurdle” technology - it’s not for the inexperienced. It establishes inhibition rather than kill - so may not give a PET “pass”. Compromise of any factor - even temporarily in making - can bring the house down.
In any case, good luck CHarley!
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I’ll add
PET (USP? Iso?) is validated to neither manufacturing nor consumer protection. It merely says you have a degree of efficacy. Design a system that should work and confirm it at least passes in the PET.
NO single preservative is effectively broad spectrum - that is nothing but supplier salesmanship. -
As Pharma is spot on.
Natacide is a proprietary mixture. You should NOT use anything as preservative whose composition is not known and specified in CoA. The preservative is the only ingredient used exclusively for a safety purpose in your product, and you should not delegate safety to Synerga.Do not use this stuff..
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Don’t have the info for this product.
Re your 2nd question - there is info. Micro recalls are certainly up for cosmetics esp. in last decade, and virtually all with natural/naturally compliant preservatives systems. FDA talked about this https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/lam.12995
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Wonder at use of DMSO. Maybe pharma can comment - didn’t see that factor controlled.
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Apparently Lush thinks it does.
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The organic acids you’re using are pretty poor by themselves..
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Think Biocriol WS1 is a bad idea for an aerosolized product. The isothiazolinones can be sensitizers - that’s why they’re not used in leave-on cosmetics.
Sensitization in an aerosolized context could lead to anaphylaxis. -
what goes into solution
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General considerations https://cosmeticseurope.eu/files/5914/6407/8121/Guidelines_on_Stability_Testing_of_Cosmetics_CE-CTFA_-_2004.pdf
The primary elements are safety (esp. preservative efficacy) and performance stability (emulsion, esthetics, pH etc.) for regulatory - e.g. weight.
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With the contamination you mentioned, probably the latter with EDTA. Your primary fix must be in bringing GMP’s, manufacturing hygiene and possible biofilm into control..
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Piroctone olamine was used for dandruff. Hair thinning was not its intent - this is tangentdial - a potential, limited benefit. P&G never made the relevant claim.
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MurtazaHakim said:Sodium benzoate’s activity is very low at pH above 5 and liquid hand soaps usually have pH ranging from 5.5-7.5.
Re. Na benzoate, In presence of some surfactants, the pKa is effectively increased. I’ve found effect at 7 . Please look at labels - CMIT/Na Benzoate is in Head & Shoulders, Pantene, Herbal essences, Aussie - all pH well above pKa.
Lonzaserve ID is a combination of DMDM Hydantoin and CMIT - very effective but prob overkill as they share the same primary spectrum of efficacy tho discouraging adaptation. might be advisable if you’ve a resistant bug in your manufacturing system.