MarkBroussard
Forum Replies Created
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Yes, all you have to do is use a bit of lactic or citric acid to drop the pH a bit. I always adjust to this pH range unless there is a main ingredient incompatability that requires a higher or lower pH.
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The general pH range for human skin is 4.8 - 5.3 or so. If you want to develop a “pH balanced” product, then formulate in this range. It’s alway a bit better to have your products on the lower end of the range since the acid mantle recovers more quickly from an acidic pH disruption than a basic pH disruption when a skin care product is applied.
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Dehyroxanthan Gum will actually decrease the viscosity of your emulsion, depending on the ingredients … it is quite difficult to work with and is actually an ingredient used in hair styling products … it is not a general purpose thickening gum for skin care products. Unless you are making a hair styling product, best you avoid it.
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Why not just use Euxyl PE 9010: Phenoxyethanol (and) Ethylhexylglycerin
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BASF has a product that is Salicylic Acid complexed with Acacia Gum that is a spray-dried solid and goes right into solution in water, no other solvent required. You might cost compare that ingredient versus Salicylic Acid + Propanediol + Propylene Glycol. It’s very easy to formulate with.
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That I do not. Obviously, there have been lots of projects for hand sanitizers the past few months. I made BenzAlk sanitizer prototypes with and without CETAC is how I know the skin sensorial gets unacceptable above 1% or so. Much easier and more effective to just use BenzAlk, imho.
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1% to 2% CETAC should do the trick. But, CETAC is not nearly as effective an antimicrobial as Benzalkonium Chloride ( use level is 0.10% to .12% ) and the CETAC does make the product sticky, but perhaps not so much in an antibacterial liquid soap.
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You can use Propanediol at any percent you want … it’s all a matter of cost and sensorial. In a Lotion, 2% should be just fine … you’ll get the added benefit of boosting your preservative in addition to moisturization.
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You will need on the order of 25% to 30% Propanediol. Add 1% Sodium Citrate and that will help solubilize the SA. As mentioned above, ditch the NaOH. Keep your pH between 3.0 and 4.0. Add 2% Polysorbate 80.
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In cosmetics, you’re better off using the trade secrets route than patents. Patents would only really be relevant if you have a proprietary ingredient or combination of ingredients that have some specific effect/benefit.
Then the issue becomes that you have to defend the patent which can be quite an undertaking unto itself. Just not worth the effort.
It’s easy enough to work around most patents anyhow.
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Selling to the Professional market as opposed to the mass consumer market is a marketing/distribution channel strategy. Several companies pursue this approach.
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(1) If the product you are selling contains an ingredient that in designated as an OTC drug active ingredient, such as Benzoyl Peroxide for acne treatment products, then your product is an OTC drug product and must comply with the Acne OTC Monograph regardless of whether or not the product is being sold to the professional market or the consumer market. If it contains an OTC active, you must comply with the monograph. OTC products must be registered with the FDA and manufactured in an OTC-approved facility.
(2) If your product does not contain an OTC active, it is a cosmetic product. You can sell cosmetic products to either or both the Professional market and the Consumer market. You do not have to register cosmetic products with the FDA, it is an optional registration.
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@esthetician922: Yes, if your products are sold only to the Professional market (Estheticians, Dermatologists, etc.) and not to the general public, there are are a different set of labeling requirements. It’s not a “loophole” … the regulations are designed specifically for the purpose of products sold in the Professional-only market.
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“Better” is a relative term … “Better” in what context?
“Better” meaning it is more effective? Or, easier to incorporate into a formula? Or, more stable?
Depending on your product format, say a cream … then, Yes, SAP would be better than LAA in terms of your cream not discoloring so quickly.
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Try Ultrez-10
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Ultrez-21 will not give you sufficient viscosity in a hydroalcoholic solution … use Carbomer instead at 0.5%
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The stabilizers are generally tin-based compounds
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No, I’ve made teeth whitening gels with 12% H2O2 … the H2O2 contains stabilizers that are quite effective and are designed for the professional market, not the consumer market.
The common hydrogen peroxide solutions you buy at the pharmacy contain 3% H2O2.
Granted, a solution with 12% H2O2 doesn’t feel particularly good when applied to the skin, it is tolerable.
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The recommendation on ethanol is at least 60% ethanol (v/v) is required to be effective at sanitizing. I don’t know if 80% is necessarily more effective than 60%.
If alcohol is applied to the skin any lipids that “dissolve” in the alcohol will simply be redeposited on the skin surface when the alcohol evaporates … the lipids are not volative. However, if you use an alcohol wipe, then of course you are going to remove some of the lipids through mechanical action.
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Yes, I recall reading a study in which it was determined that Ethanol was not drying to the skin. I ready another study that concluded that the addition of Glycerin to the Ethanol/Water mixture was actually less effective at killing microbes than mixtures without Glycerin. A third study indicated that Wipes were more effective than either Gels or Sprays or Foams. But, properly washing your hands was the most effective of all.
As @Belassi correctly pointed out, Benzalkonium Chloride would be a much better addition to the WHO formula than glycerin. Hydrogen Peroxide is a nice to have, but not critical. Your best performing base formula would be Ethanol 60%-70% (v/v), Benzalkonium Chloride 1.2% (w/w) and Water.
If you’re concerned about drying the skin … simply use a hand moisturizer after you have used the sanitizer.
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AQUA 29%, CAMELLIA JAPONICA FLOWER WATER 20%, ADANSONIA DIGITATA LEAF EXTRACT 12%, HYALURONIC ACID 7%,
HYDROGENATED RETINOL 4%,
CETEARYL OLIVATE + SORBITAN OLIVATE 4%,
ASCORBIC ACID (VITAMIN C) 4%,
HAMAMELIS VIRGINIANA EXTRACT 4%,
ALOE BARBADENSIS LEAF JUICE 4%,
AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) EXTRACT 4%,
ADONIS AMURENSIS EXTRACT 2%,
ALLANTOIN 2%,
NIACINAMIDE 2%,
LACTOBACILLUS FERMENT 2%
When in doubt, follow the 4%/2% rule of formulating … LOL. -
@klangridge:
Hydrogen Peroxide is included in the WHO formula primarily because it is an effective biocide against spores.
Glycerol is included in the formula as a humectant to help moisturize the skin. The study said “significantly reduces” … but they did not enumerate what they mean by “significant”
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Yes, this is all getting rather silly as the only thing that really matters is complete coverage of the hands and sufficient contact time.
One should only be using Hand Sanitizer if hand washing is not available since it is known that hand sanitizer is no more effective than hand washing for 30 seconds. And, if your hands are dirty, it reduces the effectiveness of the hand sanitizer.
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It’s easy enough to calibrate a pump to deliver a specified quantity of product. The major issue is actually cleansing well under the fingernails which is where most pathogenic germs/microbes “hide” … the issue is not the format of the product, sprays and gels will work equally well if used properly.
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The fallacy in all of this argument is the assumption that consumer will use a spray improperly, but will use a gel properly. That’s not a good assumption at all.
You can write the clearest directions possible on any product … the issue is will the consumer even bother to read it. For something so simple as a hand sanitizer, I would assume most people think they know how to use a hand sanitizer without feeling the need to read the directions.