Creamycreamygel
Forum Replies Created
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@chemicalmatt thank you for your input. I have reviewed quite a few studies and seems like transcutol is most effective at higher concentrations, that’s why I’m using it this way. As for propylene glycol, maybe I should drop it altogether, because pentoxifylline solubility seems pretty low from my experiments.<div>
Solubility in transcutol seems to be the same as in water, around 50-60mg/ml.
I think I will probably have to move to an emulsion with oleic acid, because that would likely be much more effective than a gel anyways and maybe would prevent this problem altogether. It’s just that I’m not yet sure where to order a small amount of Lubrizol Pemulen TR-1 or TR-2.. since that seems like the easiest way for a DIY project with limited equipment.
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@evchem2 do you think carbopol 940 would also work in this scenario? I’m also thinking about potentially replacing oleic acid with isopropyl myristate, but not necessarily.
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HEC 2%
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It seems that saponification isn’t really used that often in transdermal preparations? I wonder why?
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Thank you! I will consider my options! Is there a way to get a consultation (for a fee) from some of you guys in case I need more help?
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Thank you, that’s very helpful. Could you give a few examples of emulsifiers that I could consider, both polymeric and more traditional?
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Hi, thank you very much for replying. Any reason not to use something like polysorbate 80?