[Chemist5000]

Gentleman thank you again.  
My boss is a sales woman and not a scientist.  What ever is trending is what she wants….  
I am sure my boss is open to new things but right now she wants this as apart of our line of products.  Some of our clients have been asking for it too.  It is the “buzz word” for lubes right now.  

[Chemist5000]

@markbroussard and @johnb

Thank you gentleman.  

Understand this is still all new to me and I don’t have the guidance of a on staff mentor.  So what may be a simpler method for you (after years of experience) doesn’t come as elementary for me.  In some of my experience, R&D Chemists can be down right snobby about being helpful.  I am very grateful each of you and for this website to as a helpful source of sharing knowledge…

My benchmark is a competitor hybrid lubricant and I am using similar chemicals as listed on the ingredient deck and what is available to me at this time.  I am trying to reproduce what the last chemist was working on.

@johnb
I will be looking into getting another grade of natrosol today!  Hybrid lubes right now are the “hip” thing in personal lubes.  However I am totally open into doing something differ@johnb

@MarkBroussard
I am extremely in doing what you are suggesting.  My boss has her heart set on a water/silicone because that is what other companies are offering.  What gelling agent would you suggest with hyaluronic acid.     

Again thanks.

[Chemist5000]

Okay this formula is the gift that keeps on giving….

Now my hybrid formula keeps thickening on me.  I have reduced the natrosol 250 HHR to 55%. and I have changed out the my silicones to be of lower viscosity. (PMX 200-0.65 cst @5% and PMX 200 - 0245 @ 10%) 

I have notice the thickening happening at the end of the batch when I have to adjust for clarity using my refractometer.  slightly hazy clear is acceptable. It needs to be around 3000 cps more on the “running side.”  Not sure what to do next.

[Chemist5000]

I plan to do proper stability testing with out a doubt. I am not suggestion that what I am doing is in place of real stability.  I am trying to get my current employers to understand that too.  

At a previous employment, they would make a lab batch and place a samples in ovens of various degrees (40, 45,50,55, f/t) to see if this would separate.  It was not fool proof or in place of real stability but it gave idea of the potential stability. 

They want to launch this product fairly quickly and I noticed 2 of my samples were separating in the 55°C oven. Is there no conclusion that could be ascertained at this moment?

Thanks for the correction of the 45 and 2 months.

[Chemist5000]

This is more about stability of the before mentioned vaginal lube formulation. Please correct me if I am wrong…

I made 3 versions of the water in silicone lube.  I placed the samples in a 55°C for a quickie stability check before doing “real” stability.

Sample #1 showed no signs of separation @ 55°C for 5 days
Sample #2 showed showed signs of separation @55°C after 2 days
Sample #3 immediately separated after a few hours on the same day @55°C.

Question is would my Sample #1 be deemed acceptably stable formulation for the market place? Are samples #2 & #3 acceptable with limits?

I know that 45°C for approx a month represents a year.  Thanks!

[Chemist5000]

thanks! Learning after high school never ends! 

[Chemist5000]

I am using Natrosol 250 HHR.  

My real question is do I have to adjust pH for use in the vagina at the end?  Vagina pH is 3.8 -5.0 range.  

[Chemist5000]

Question:  I am still a newbie…  My water phase has Natrosol, PG, and water.  

I have noticed that in previous formulations that small tiny lumps have been apart of the final products.   I totally want to avoid this.

Should I heat the water phase to 65-70 let it then adjust pH with NaOH to approx 8-8.5.

OR

mix my water phase at RT adjust pH to 8-8.5?

In either case this will be slowly added to a silicone phase to complete the lube.  

Typical vagina pH is 3.8- 5.0 do I need to correct the pH before the addition to the silicone phase or afterward?

Another silly question…. would final pH would be N/A because this is a W/S emulsion? Just want to make sure my thinking is correct. I am alone in the wilderness … thanks!

[Chemist5000]

@johnb this is of interested.  Thank you so much.  

[Chemist5000]

@johnb   it is a concern for the FDA though we have been dinged by this.  There are lube makers that do have products with very high osmolality.  I don’t have much knowledge on the subject matter.  I am not sure exactly what the FDA stance is on osmolality beside letting us (my job) know our product is too high.  Not sure if this is a deal breaker with the 510k or not. 

[Chemist5000]

@MarkBroussard no i haven’t I will see if we have any in stock….is it safe to put on nipples?

[Chemist5000]

@MarkBroussard  that is why I think I am going to love working in the sex biz right now.  I have both!   :p  

[Chemist5000]

@MarkBroussard   Male or female want to have more stimulation to have a better sexual experience.  I looked at the article and would be curious about the test population. 

[Chemist5000]

@MarkBroussard   Putting some type of stimulant on the clitoris is the same as for a man with Viagra to a degree.  Through health issues or old the clitoris becomes desensitized. More like what ever works… Question is does it really work? Who knows. This could a “bill of goods” or a “hope and prayer”.

[Chemist5000]

@MarkBroussard  thanks i have all weekend to do more homework!

[Chemist5000]

@bobzchemist thanks!

[Chemist5000]

@MarkBroussard no offense taken.  I know I haven’t done alot of research yet and I am not getting alot of help from work left by the previous chemists either.  I was just given this project and learning the about complexities of it now.   If you have any suggested reading sources I am happy to research them.   

Can any body tell me how do you test for Osmolality? what is the magic range for a health vagina?

[Chemist5000]

Thanks for the suggestions!  Menthol doesn’t sound that great either.

This is an adult toy company!  As for a vagina balm with natural ingredients… Is there any rule of thumb of what “natural oils” that could be used in the vaginal area? What to avoid?  This product is suppose to help with dryness and be a daily use product for post menopausal females.  

[Chemist5000]

@MarkBroussard- thanks for the heads up! Do you have any suggestions for a female arousal stimulant? The customer said they do not want to use L-Arginine?