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Urea cream for callouses - why only 40% lotions available over the counter?
I checked the FDA website but see no rule making / monographs on using urea for callouses or on skin in general, there was a panel looking into it in 2003 but no rules were made.
Could it be a formulation issue with urea out crystallizing at > 40%. How would you make a 50% cream (which could be useful for callous removal).Cheers! -
2 Replies
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You will not be able to incorporate any more urea than 40% (if that much), since you’ll exceed it’s water solubility saturation point. Urea only softens skin - and callouses. It does not actually “treat” callouses or remove them like a keratolytic agent would. That is likely the reason FDA hedged. I would classify urea creams as homeopathic remedies. They have been around for over 70 years.
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There are 50% urea treatments available and if breaking up part of the skin matrix is callouses, here’s one:CARBOMER COPOLYMER TYPE A.ALPHA.-TOCOPHEROL ACETATE, DL-EDETATE DISODIUMGLYCERINLACTIC ACIDMINERAL OILPOLYSORBATE 85WATERSODIUM HYDROXIDESTEARIC ACIDPYRITHIONE ZINCHomeopathy refers to the use of minute doses of a treatment in most definitions of the word.
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