As a formulator of toothpaste (I tend to work to Natrue standards, so some of the ingredients you’ve listed are not permitted under this standard, and as such, I have little experience of them).
First thing I notice - no abrasives. You mentioned calcium carbonate and sodium bicarbonate “as needed”. I’m unsure whether you mean this to be used as an abrasive or whether you are thinking to manage pH. - but unsure if you mean these to be abrasives. You could consider, silicon dioxide (there are gel grades and abrasive grades).
“Glycerol/Sorbitol” - 35-60%. 35-40% is more around the level you want. Too high, you end up with a paste that looks more plasticy. I have one formula with the glycerol around 20% - it produces a dull looking flat paste, that solidifies rather quickly in air - and I would reduce this, but because the glycerol/Xylitol/Steviol glycosides produced a sweetness almost comparable with saccharine - I am stuck with it)
CAPB/Coco Glucoside - Levels look about right but you will need to experiment to see how it affects the flavour of your toothastes.
Preservatives - We don’t use any. We have tested to BP standards, cosmetic microbiology standards, USP standards. As well as testing water activity. We have done ambient and accelerated stability, and tested it every way we can. We have proven we don’t need it. However, if you are not prepared to test to the levels we have, use preservatives - and parabens are the best in toothpaste. There are other options available - but potassium sorbate will not work at all with a calcium carbonate or sodium bicarbonate paste (pH is 8-8.5), and very limited use in a silicon dioxide gel - because you will need to lower pH further and this is not great for teeth.
Triclosan - I don’t use it. It also seems to be restricted in the markets we generally sell in.
To answer your specific questions.
Yes, you can have a toothpaste without calcium carbonate in it - but consider the options you do want to use as an abrasive. Silicon dioxide abrasives such as Evonik Zeodent grades have targeted RDA/PCR at a particular usage rate. Bicarb abrasiveness depends on particle size. There are others you can use.
Thickener - I would use Sodium carboxymethylcellulose (Cellulose gum) every time. But that is a personal preference based on experience
Surfactants - most use SLS because it is the easiest to work with and has fewer off flavours to work with. I use Lauryl glucoside and sodium cocoyl glutamate. Seems our marketing team and customers expect product to be free from SLS. The ones I use do impart some off flavours that are hard to mask.
pH range - I wouldn’t go below pH 5.5. This was recommended to us by the good chaps at OHRI at Indiana Uni.
Fluoride - there is no replacement for fluoride. The trend is towards using nano-hydroxyapatite, but fluoride really does bind to teh calcium in teeth and strengthen them. If you use fluoride, avoid using it in a calcium carbonate toothpaste. The total fluoride will remain at the levels on input, but the free-fluoride will drop and sodium fluoride or sodium monofluorophosphate will react over time reducing your free-fluoride (which does nothing to help teeth). Triclosan will not replace fluoride.
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This reply was modified 1 month ago by Herbnerd.