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Tagged: tocopherol, vit-e
Tocopherol (Vit. E) LiquidPosted by tinj on May 29, 2019 at 3:28 am
Hello. Would like to ask if it is normal the Vit.E liquid that I bought is clear white, slightly viscuous (syrupy) and smells a bit like alcohol?
This is supposed to be for cosmetics to prevent it from turning rancid. The supplier said the expiry date is on 2021.Dr Catherine Pratt replied 3 years, 8 months ago 8 Members · 28 Replies
DoreenMemberMay 29, 2019 at 1:22 pm
Colour is usually amber to light brown, certainly not white.
(Source of picture)
crillzMemberMay 30, 2019 at 3:10 am
Ours is clear white slight viscous as mentioned, syrupy.
MarkBroussardProfessional Chemist / FormulatorMay 31, 2019 at 1:45 am
If it is clear “white” … it should be translucent, then what you have is Tocopheryl Acetate
DtdangMemberMay 31, 2019 at 1:53 am
@MarkBroussard, what are differences between vitamin E and
MarkBroussardProfessional Chemist / FormulatorMay 31, 2019 at 12:28 pm
Tocopherol acetate is a snythetic ester made from natural tocopherol. The ester is more stable against going rancid than the natural tocopherol. The both perform essentially the same function.
DtdangMemberMay 31, 2019 at 12:46 pm
@MarkBroussard thanks a lot.
PharmaMemberJune 1, 2019 at 2:11 pm
Tocopheryl acetate is not an antioxidant and will not protect the product but become active only after penetrating skin and doing it’s work there. Tocopherol on the other hand is primarily used to protect the product from getting rancid and is usually not used as an active ingredient (unless tocopheryl acetate can not be used because it’s synthetic).
DoreenMemberJune 1, 2019 at 6:41 pm
Correct. I see a lot of homecrafters using vitamine E capsules (the acetate form) as antioxidant for their product, but it’s useless for that reason.
Tocopheryl acetate => as skin ‘active’
Tocopherol => as antioxidant for product or raw ingredients (e.g. vegetable oils), no more than 0.2% or it stimulates oxidation rather than inhibits.
MarkBroussardProfessional Chemist / FormulatorJune 1, 2019 at 11:52 pm
It’s actually a bit more complicated than that. Tocopherol is the biologically-active form of Vitamin E and is found primarily in the epidermis and sebum, but it is easily oxidized. When applied topically, it does penetrate into the epidermis and increases total tocopherol content and provides significant skin benefits, primarily as a free-radical scavenger.
Tocopherol Acetate is much more stable, but the conversion rate to free tocopherol when applied topically is at best 6%, so topically-applied tocopherol acetate isn’t really doing very much. Tocopherol, when applied topically is documented to substantially increase the tocopherol content in the skin for up to 24 hours.
Yes, you can use both in the same formulation. The key is to add “co-antioxidants” to stabilize the tocopherol such as Ferulic Acid, Grape Seed Extract, Resveratrol, Green Tea catechins, Vitamin C, Ubiquinone. It all depends on your product form as to which of the above co-antioxidants are appropriate to use. You can also mix tocopherol, tocotrienols and tocopherol acetate.
PharmaMemberJune 2, 2019 at 7:53 amMarkBroussard said:…but the conversion rate to free tocopherol when applied topically is at best 6%, so topically-applied tocopherol acetate isn’t really doing very much…
Ugh, that bad? Never paid any heed to that point. Thanks!
DoreenMemberJune 2, 2019 at 8:38 am
Tocopherol acetate doesn’t have antioxidant activity in the product or raw ingredient, so best to use ‘pure’ tocopherol for that reason (which is amber coloured). And as Mark rightfully mentions it’s not very stable, so indeed a good idea to pair it up with the substances that he mentions.
Disadvantage of (alpha-)tocopherol is that you shouldn’t exceed 0.2% or it can become pro-oxidative (see graph below).
Personally I never use tocopherol acetate. I don’t see a good reason for it.
Edit: gamma and delta tocopherol don’t become ‘pro-oxidative’ in higher doses. Manufacturer Jan Dekker for example has products without alpha-tocopherol, so these can be used in higher %.
I still can’t upload files in replies, only in private messages.
MarkBroussardProfessional Chemist / FormulatorJune 2, 2019 at 12:41 pm
I think you are missing the interpretation in that graph in your statement that you should not use Tocopherol above 0.2%.
The graph is showing the rate of diene conversion at different temperatures … what that graph is actually showing is that as the temperature increases, the rate of diene formation increases given the same amount of tocopherol.
It is not supporting that tocopherol becomes significantly pro-oxidative at concentrations above 0.2%. What is is showing is that at concentrations above 100 ppm, you really are not getting any additional benefit from the addition of more alpha-tocopherol.
The most relevant line in the graph is the 40C trend line which is closest to normal skin temperature (32.5C) and rises to 33.5C, on average, when sunbathing.
The 60C trend line equates to 140F … skin temperature only gets that high if you are on fire, so it has no real relevance.
DoreenMemberJune 2, 2019 at 4:26 pm
I now see that what I took for the 40C line is actually the 60C line and the lower temperatures indeed don’t increase the conjugated diene forming significantly. Thanks for pointing it out!
(The used medium in this graph is pure sunflower oil by the way (without other additions). I have no idea how and if the graph would change when it would be e.g. an emulsion.)
What concentration would you recommend for skin benefits?
MarkBroussardProfessional Chemist / FormulatorJune 2, 2019 at 5:15 pm
There is no “correct” amount to use … I generally use Tocopherol and Tocotrienols at 0.5%.
tinjMemberJune 3, 2019 at 2:32 pm
Thank you so much for the insights. Btw, this is how it looks like when I draw it out using tuberculin syringe..yes, translucent.. far different from the amber colored tocopherol..
MarkBroussardProfessional Chemist / FormulatorJune 3, 2019 at 2:39 pm
Honestly, that does not even look like Tocopherol Acetate, which should be a translucent yellow color … this looks crystal clear.
PharmaMemberJune 3, 2019 at 5:59 pm
Pure tocopherol and tocopherol acetate have the consistency of liquid honey, very viscous. If it’s more like syrup or even water, then it’s a dilution of some kind.
AnonymousGuestSeptember 5, 2019 at 9:45 pm
Can anyone speak more about vitamin E acetate in vape devices? I am on an epi team and we’re keeping an eye on these recently reported lung illnesses linked to vaping devices.
I suspect vit E acetate is being used to preserve the e-liquid to prevent it from becoming rancid, but are there other reasons it would be added or other issues if it’s heated, handled, inhaled instead of consumed, etc…could it be in certain flavors and not in others…Thoughts??