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Solvents for water insoluble actives
I am trying to perfect a formula strictly for personal use. It consists of a 50/50 of 95% ethanol/pg base and then I add a particular substituted phenol to bring it to 15% by weight. It is completely water insoluble, its slightly soluble in pg, soluble in ethanol. When the ethanol evaporates off my skin some crystallises. I’m sure you can see the problem there. It is probably harsh, but I tolerate it well. A water base is not possible because I don’t have equipment for micronization. I tried antisolvent precipitation in an ultrasonic bath but it degraded.I also make small batches to limit any degradation and the speed and ease dissolving it is worth some irritation.
My main problem is the amount of common excipients that are incompatible with phenols because of peroxide impurities. I’m looking for a way to either prevent crystallisation from the ethanol or a new solvent all together that won’t evaporate as quickly and is affordable.
Would appreciate any input. Thank you ????
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